Journal ArticleDOI
Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations
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Qualitative and quantitative investigations on the metabolism in rat-liver preparations of eleven tritiated hydrocarbons showed that all the major ethyl acetate-soluble metabolites of these Hydrocarbons have been recognised: in most cases the structure of the metabolites have been confirmed.About:
This article is published in Biochemical Pharmacology.The article was published on 1970-03-01. It has received 256 citations till now. The article focuses on the topics: Methylcholanthrene & Pyrene.read more
Citations
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Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
TL;DR: It is suggested that epoxides are the important reactive metabolites responsible for the biological effects of these carcinogens4.
Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal ArticleDOI
Arene oxides: a new aspect of drug metabolism.
Donald M. Jerina,John W. Daly +1 more
Journal ArticleDOI
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
TL;DR: Whether a given aromatic or olefinic compound produces such an effect would depend on a variety of factors, such as the relative rate of formation and degradation of the intermediate oxirane, on its stability with respect to spontaneous isomerization to the corresponding phenol and on its chemical electrophilic reactivity.
Book ChapterDOI
Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.
P. Sims,P.L. Grover +1 more
TL;DR: This chapter discusses the role of intermediates such as free radicals, radical cations, and carbonium ions in polycyclic hydrocarbon carcinogenesis, and discusses the factors that can influence the formation, further metabolism, and biological effectiveness of polycyclIC hydrocarbon epoxides.
References
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Journal ArticleDOI
An enzyme from rat liver catalysing conjugations with glutathione
J. Booth,E. Boyland,Peter Sims +2 more
Journal ArticleDOI
Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver.
TL;DR: Data is presented here on the induced synthesis of a benzpyrene-metabolizing system by 3,4-benzpyrene and related hydrocarbons, which occurs in the liver microsomes and requires TPNH and oxygen for activity.
Book ChapterDOI
Electronic structure and carcinogenic activity of aromatic molecules: new developments.
A. Pullman,B. Pullman +1 more
TL;DR: The correlations established between electronic characteristics, chemical reactivity, and carcinogenic activity of aromatic molecules point to the conclusion that the mechanism of action of carcinogenic molecules involves at least, at one of its stages, a chemical reaction between the carcinogen aid and a cellular receiver.