Quality control of mitochondria: protection against neurodegeneration and ageing
Takashi Tatsuta,Thomas Langer +1 more
Reads0
Chats0
TLDR
Current knowledge on surveillance strategies that limit mitochondrial damage and ensure cellular integrity and their role in human disease are summarized.Abstract:
Dysfunction of mitochondria has severe cellular consequences and is linked to ageing and neurodegeneration in human. Several surveillance strategies have evolved that limit mitochondrial damage and ensure cellular integrity. Intraorganellar proteases conduct protein quality control and exert regulatory functions, membrane fusion and fission allow mitochondrial content mixing within a cell, and the autophagic degradation of severely damaged mitochondria protects against apoptosis. Here, we will summarize the current knowledge on these surveillance strategies and their role in human disease.read more
Citations
More filters
Journal ArticleDOI
The axonal transport of mitochondria
TL;DR: Why mitochondria move and how they move is reviewed, focusing particularly on recent studies of transport regulation, which implicate control of motor activity by specific cell-signaling pathways, regulation of motor access to transport tracks and static microtubule–mitochondrion linkers.
Journal ArticleDOI
Essential role for Nix in autophagic maturation of erythroid cells
Hector Sandoval,Perumal Thiagarajan,Swapan K. Dasgupta,Armin Schumacher,Josef T. Prchal,Min Chen,Jin Wang +6 more
TL;DR: It is suggested that Nix-dependent loss of ΔΨm is important for targeting the mitochondria into autophagosomes for clearance during erythroid maturation, and interference with this function impairs erythyroidmaturation and results in anaemia.
Journal ArticleDOI
Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
TL;DR: It is demonstrated that, in post-log phase cells under respiratory conditions, a substantial fraction of mitochondria are exclusively sequestered as cargoes and transported to the vacuole, a lytic compartment in yeast, in an autophagy-dependent manner and suggested that Atg32, a mitochondria-anchored protein essential for mitophagy that is induced during respiratory growth, interacts with Atg8 and Atg11, autophatic proteins critical for recognition of cargo receptors.
Journal ArticleDOI
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
Amrita M. Nargund,Mark W. Pellegrino,Christopher J. Fiorese,Christopher J. Fiorese,Brooke M. Baker,Cole M. Haynes,Cole M. Haynes +6 more
TL;DR: The mechanism by which ATFS-1 (activating transcription factor associated with stress–1) senses mitochondrial stress and communicates with the nucleus during the mitochondrial unfolded protein response (UPRmt) in Caenorhabditis elegans is examined and it is found that the key point of regulation is the mitochondrial import efficiency of ATfs-1.
Journal ArticleDOI
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Zu-Hang Sheng,Qian Cai,Qian Cai +2 more
TL;DR: Research into the mechanisms that regulate mitochondrial transport is an important emerging frontier into the pathogenesis of several major neurological disorders.
References
More filters
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Journal ArticleDOI
Mitochondrial Membrane Permeabilization in Cell Death
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
Journal ArticleDOI
Self-eating and self-killing: crosstalk between autophagy and apoptosis
TL;DR: The functional relationship between apoptosis and autophagy is complex in the sense that, under certain circumstances,autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
Journal ArticleDOI
Function and regulation of cullin-RING ubiquitin ligases.
TL;DR: This review focuses on the composition, regulation and function of cullin–RING ligases, and describes how these enzymes can be characterized by a set of general principles.