Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing.
Luca Ferretti,Chris Wymant,Michelle Kendall,Lele Zhao,Anel Nurtay,Lucie Abeler-Dörner,Michael Parker,David Bonsall,Christophe Fraser +8 more
Reads0
Chats0
TLDR
A mathematical model for infectiousness was developed to estimate the basic reproductive number R0 and to quantify the contribution of different transmission routes and the requirements for successful contact tracing, and the combination of two key parameters needed to reduce R0 to less than 1 was determined.Abstract:
The newly emergent human virus SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) is resulting in high fatality rates and incapacitated health systems. Preventing further transmission is a priority. We analyzed key parameters of epidemic spread to estimate the contribution of different transmission routes and determine requirements for case isolation and contact tracing needed to stop the epidemic. Although SARS-CoV-2 is spreading too fast to be contained by manual contact tracing, it could be controlled if this process were faster, more efficient, and happened at scale. A contact-tracing app that builds a memory of proximity contacts and immediately notifies contacts of positive cases can achieve epidemic control if used by enough people. By targeting recommendations to only those at risk, epidemics could be contained without resorting to mass quarantines ("lockdowns") that are harmful to society. We discuss the ethical requirements for an intervention of this kind.read more
Citations
More filters
Journal ArticleDOI
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period.
TL;DR: Using existing data to build a deterministic model of multiyear interactions between existing coronaviruses, with a focus on the United States, is used to project the potential epidemic dynamics and pressures on critical care capacity over the next 5 years and projected that recurrent wintertime outbreaks of SARS-CoV-2 will probably occur after the initial, most severe pandemic wave.
Journal ArticleDOI
Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.
Qifang Bi,Yongsheng Wu,Shujiang Mei,Chenfei Ye,Xuan Zou,Zhen Zhang,Xiaojian Liu,Lan Wei,Shaun A. Truelove,Tong Zhang,Wei Gao,Cong Cheng,Xiujuan Tang,Xiaoliang Wu,Yu Wu,Binbin Sun,Suli Huang,Yu Sun,Juncen Zhang,Ting Ma,Justin Lessler,Tiejian Feng +21 more
TL;DR: An analysis of data from the Shenzhen Center for Disease Control and Prevention identified 391 SARS-CoV-2 cases and 1286 close contacts shows that isolation and contact tracing reduce the time during which cases are infectious in the community, thereby reducing the R.
Journal ArticleDOI
Identifying airborne transmission as the dominant route for the spread of COVID-19.
TL;DR: It is concluded that wearing of face masks in public corresponds to the most effective means to prevent interhuman transmission, and this inexpensive practice, in conjunction with simultaneous social distancing, quarantine, and contact tracing, represents the most likely fighting opportunity to stop the COVID-19 pandemic.
Journal ArticleDOI
Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures.
Marino Gatto,Enrico Bertuzzo,Lorenzo Mari,Stefano Miccoli,Luca Carraro,Renato Casagrandi,Andrea Rinaldo +6 more
TL;DR: Although a number of assumptions need to be reexamined, like age structure in social mixing patterns and in the distribution of mobility, hospitalization, and fatality, it is concluded that verifiable evidence exists to support the planning of emergency measures.
References
More filters
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Temporal dynamics in viral shedding and transmissibility of COVID-19.
Xi He,Eric H. Y. Lau,Peng Wu,Xilong Deng,Jian Wang,Xinxin Hao,Yiu Chung Lau,Jessica Y. Wong,Yujuan Guan,Xinghua Tan,Xiaoneng Mo,Yanqing Chen,Baolin Liao,Weilie Chen,Fengyu Hu,Qing Zhang,Mingqiu Zhong,Yanrong Wu,Lingzhai Zhao,Fuchun Zhang,Benjamin J. Cowling,Fang Li,Gabriel M. Leung +22 more
TL;DR: It is estimated that 44% (95% confidence interval, 25–69%) of secondary cases were infected during the index cases’ presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home.
Journal ArticleDOI
Presumed Asymptomatic Carrier Transmission of COVID-19.
TL;DR: This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei.
Related Papers (5)
Temporal dynamics in viral shedding and transmissibility of COVID-19.
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)
Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand
Neil M. Ferguson,Daniel J Laydon,G Nedjati Gilani,Natsuko Imai,Kylie E. C. Ainslie,Marc Baguelin,Sangeeta N. Bhatia,A Boonyasiri,Z Cucunuba Perez,Gina Cuomo-Dannenburg,Amy Dighe,Ilaria Dorigatti,Han Fu,Katy A. M. Gaythorpe,W Green,Arran Hamlet,Wes Hinsley,Lucy C Okell,S Van Elsland,H Thompson,Robert Verity,Erik M. Volz,Haowei Wang,Y Wang,Patrick G T Walker,Caroline E. Walters,Peter Winskill,Charles Whittaker,Christl A. Donnelly,Steven Riley,Azra C. Ghani +30 more