Journal ArticleDOI
Quantitative breath analysis of volatile organic compounds of lung cancer patients.
Geng Song,Tao Qin,Hu Liu,Guo-Bing Xu,Yueyin Pan,Fu-xing Xiong,Kangsheng Gu,Guoping Sun,Zhen-dong Chen +8 more
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TLDR
The data showed that 1-butanol and 3-hydroxy-2-butanone in breath could possibly be taken as useful breath biomarkers for discerning potential lung cancer patients and VOCs analysis could be used as a complementary test for the diagnosis of lung cancer.About:
This article is published in Lung Cancer.The article was published on 2010-02-01. It has received 232 citations till now. The article focuses on the topics: Breath gas analysis & Breath test.read more
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Assessment, origin, and implementation of breath volatile cancer markers
Hossam Haick,Yoav Y. Broza,Pawel Mochalski,Vera Ruzsanyi,Vera Ruzsanyi,Anton Amann,Anton Amann +6 more
TL;DR: This review presents a list of 115 validated cancer-related VOCs published in the literature during the past decade, and classify them with respect to their "fat-to-blood" and "blood- to-air" partition coefficients, which provide an estimation of the relative concentrations of V OCs in alveolar breath, in blood and in the fat compartments of the human body.
Journal ArticleDOI
Selective Surface Enhanced Raman Scattering for Quantitative Detection of Lung Cancer Biomarkers in Superparticle@MOF Structure.
TL;DR: Gaseous aldehydes that are released as a result of tumor-specific tissue composition and metabolism, thereby acting as indicators of lung cancer, are guided onto SERS-active GSPs substrates through a ZIF-8 channel, demonstrating tremendous prospects for in vitro diagnoses of early stage lung cancer.
Journal ArticleDOI
Room-temperature mid-infrared single-photon spectral imaging
TL;DR: In this article, an upconversion system for field-deployable mid-infrared spectral imaging is presented, which provides a room-temperature dark noise of 0.2 photons per spatial element per second, a billion times below the dark noise level of cryogenically cooled cameras.
Journal ArticleDOI
A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions.
Xu Zq,Yoav Y. Broza,Ionsecu R,Ulrike Tisch,Ding L,Hu Liu,Song Q,Yueyin Pan,Xiong Fx,Gu Ks,Sun Gp,Chen Zd,Marcis Leja,Hossam Haick +13 more
TL;DR: The preliminary results of this pilot study could open a new and promising avenue to diagnose GC and distinguish it from other gastric diseases.
Journal ArticleDOI
Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer.
Peter J. Mazzone,Xiaofeng Wang,Yaomin Xu,Tarek Mekhail,Mary Beukemann,Jie Na,Jonathan W. Kemling,Kenneth S. Suslick,Madhu Sasidhar +8 more
TL;DR: A colorimetric sensor array is capable of identifying exhaled breath biosignatures of lung cancer and can be optimized by evaluating specific histologies and incorporating clinical risk factors.
References
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Journal ArticleDOI
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
J. Guillermo Paez,Pasi A. Jänne,Pasi A. Jänne,Jeffrey C. Lee,Sean Tracy,Heidi Greulich,Heidi Greulich,Stacey Gabriel,Paula Herman,Frederic J. Kaye,Neal I. Lindeman,Titus J. Boggon,Katsuhiko Naoki,Hidefumini Sasaki,Yoshitaka Fujii,Michael J. Eck,William R. Sellers,William R. Sellers,William R. Sellers,Bruce E. Johnson,Bruce E. Johnson,Matthew Meyerson,Matthew Meyerson +22 more
TL;DR: Results suggest that EGFR mutations may predict sensitivity to gefitinib, and treatment with the EGFR kinase inhibitor gefitsinib causes tumor regression in some patients with NSCLC, more frequently in Japan.
Journal ArticleDOI
Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer.
Helen Wiseman,Barry Halliwell +1 more
TL;DR: ROS and RNS could contribute to the initiation of cancer, in addition to being important in the promotion and progression phases, as evidence is growing that antioxidants may prevent or delay the onset of some types of cancer.
Journal ArticleDOI
Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
Journal ArticleDOI
Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography
TL;DR: By this technique, the composition of body fluids can be made constant after a few days, permitting significant quantitative analyses to be performed, and should be useful in the application of the principles of orthomolecular medicine.
Journal ArticleDOI
Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study.
Michael Phillips,Kevin Gleeson,J. Michael B. Hughes,Joel Greenberg,Renee N. Cataneo,Leigh Baker,W Patrick McVay +6 more
TL;DR: A combination of 22 breath VOCs, predominantly alkanes, alkane derivatives, and benzene derivatives, discriminated between patients with and without lung cancer, regardless of stage.
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