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Quantitative Elastography of Liver Fibrosis and Spleen Stiffness in Chronic Hepatitis B Carriers: Comparison of Shear-Wave Elastography and Transient Elastography with Liver Biopsy Correlation

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TLDR
SWElastography provides more accurate correlation of liver elasticity with liver fibrosis stage compared with transient elastography, especially in identification of stage F2 or greater.
Abstract
Shear-wave elastography enables better biopsy correlated assessment of liver fibrosis compared with transient elastography, especially for early fibrosis, and gives objective assessment of splenic elasticity, correlated with liver fibrosis staging in chronic hepatitis B patients.

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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis.

TL;DR: Liver biopsy gives a snapshot and not an insight into the dynamic changes during the process of fibrogenesis, so immunohistochemical evaluation of cellular markers such as smooth muscle actin expression for hepatic stellate cell activation, cytokeratin 7 for labeling ductular proliferation or CD34 for visualization of sinusoidal endothelial capillarization can provide additional ‘‘functional’’ information.
References
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Journal ArticleDOI

An algorithm for the grading of activity in chronic hepatitis C

Pierre Bedossa, +1 more
- 01 Aug 1996 - 
TL;DR: A simple algorithm that generates a single activity score based on basic pathological features in chronic hepatitis C is proposed and tested, showing its accuracy is as high as that obtained using a statistical approach.
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Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis

TL;DR: Transient elastography can be performed with excellent diagnostic accuracy and independent of the underlying liver disease for the diagnosis of cirrhosis, however, for the diagnoses of significant fibrosis, a high variation of the AUROC was found that is dependent on the underlying Liver disease.
Journal ArticleDOI

Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease

TL;DR: Transient elastography is accurate in most NAFLD patients and is useful as a screening test to exclude advanced fibrosis, and liver biopsy may be considered in patients with liver stiffness of at least 7.9 kPa.
Journal ArticleDOI

Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations.

TL;DR: In the authors' experience, liver stiffness measurements are uninterpretable in nearly one in five cases, the principal reasons are obesity, particularly increased waist circumference, and limited operator experience.
Journal ArticleDOI

Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging.

TL;DR: Preliminary clinical results directly demonstrate the clinical feasibility of this new elastography technique in providing quantitative assessment of relative stiffness of breast tissues and give valuable information that is complementary to the B-mode morphologic information.
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