Quantitative quasi-static ultrasound elastography using reference layer: Ex-vivo study
01 Jul 2019-Vol. 2019, pp 7107-7110
TL;DR: The results suggest that using this approach of reference layer of known stiffness yields Young’s modulus values within 10% error compared to the ground truth.
Abstract: It is well-documented in the literature that changes in tissue elasticity are generally correlated with disease condition. In the case of diffuse liver disease, the elasticity of the liver reduces progressively. However, this change does not clearly manifest in conventional ultrasound examinations. Although quasi-static elastography is popular in clinical applications where qualitative assessment of relative tissue stiffness is enough, its potential is relatively underutilized in liver imaging due to the need for quantitative stiffness value. Recently, it was demonstrated that using a reference layer of known stiffness, one could produce quantitative modulus elastograms of the target tissue using quasi-static elastography using simulations and phantom experiments. Here, we examined the performance of this approach on ex-vivo goat liver samples and compare the estimated modulus values to that obtained from indentation measurements. The results suggest that using this approach of reference layer yields Young’s modulus values within 10% error compared to the ground truth.
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1,235 citations
"Quantitative quasi-static ultrasoun..." refers background in this paper
...Also, the liver disease staging correlates with Young’s modulus value [2, 3]....
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511 citations
"Quantitative quasi-static ultrasoun..." refers background in this paper
...Also, a small amount (1% volume/volume of N-propanol was added to get the speed of sound in phantoms to be matched with human tissue (1540 m/s) [12]....
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309 citations
"Quantitative quasi-static ultrasoun..." refers background in this paper
...Also, the liver disease staging correlates with Young’s modulus value [2, 3]....
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"Quantitative quasi-static ultrasoun..." refers background in this paper
...The use of contrast transfer efficiency may be important for Young's modulus value estimation of liver as there appears to be a modulus rangescale that is correlated to the disease stage, and therefore, requires more accuracy [9]....
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112 citations
"Quantitative quasi-static ultrasoun..." refers background in this paper
...reference material which allows for calculating the approximate Young’s modulus value [6, 8]....
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