Quantitative structure–activity relationship analysis and virtual screening studies for identifying HDAC2 inhibitors from known HDAC bioactive chemical libraries
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"Quantitative structure–activity rel..." refers background in this paper
...Currently, 18 HDACs have been identified in human and subdivided into four classes according to sequence homology: class I, II and IV (HDACs 1-11) are homologous to the yeast Rpd3/Hda1 family, and class III, including sirtuin proteins (Sirt 1–7), are homologous with the yeast Sir2 family [3]....
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"Quantitative structure–activity rel..." refers background in this paper
...Issues related to the system problems of naïve Bayes classifiers have been discussed before [62]....
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"Quantitative structure–activity rel..." refers background in this paper
...More information about these descriptor families can be found in Todeschini and Consonni [64]....
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...This is a simple information index for unsaturated bonds, calculated as Uc = log2(1 + nDB + nTB + nAB) where nDB, nTB and nAB are the number of double, triple and aromatic bonds, respectively [64]....
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