Quorum‐sensing autoinducer molecules produced by members of a multispecies biofilm promote horizontal gene transfer to Vibrio cholerae
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...cholerae in multispecies biofilms (558)....
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Cites background from "Quorum‐sensing autoinducer molecule..."
...Many additional drivers (e.g., chemical and environmental) of HGT have been identified (Hastings et al., 2004; Antonova and Hammer, 2011), including abiotic sources (Warnes et al., 2012; Kotnik, 2013)....
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"Quorum‐sensing autoinducer molecule..." refers background in this paper
...…indicate that naturally occurring MMR-deficient environmental ‘mutator’ strains of V. parahaemolyticus have increased genetic and phenotypic diversity relative to clinical isolates, suggesting that such mutator strains are also ‘promiscuous’ for interspecies DNA uptake (Hazen et al., 2009)....
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"Quorum‐sensing autoinducer molecule..." refers background in this paper
...In this study we demonstrated that comEA transcription and the horizontal acquisition of DNA by V. cholerae are induced in response to purified CAI-1 and AI-2, and also by autoinducers derived from other Vibrios co-cultured with V. cholerae within a mixed-species biofilm....
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...4), which encodes a V. cholerae QS pathway (Hammer & Bassler, 2008)....
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...As with V. cholerae, the maximal transformation frequency occurred with the WT V. harveyi strain, which produces both CAI-1 and AI-2....
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...Recognizing that many Vibrios possess V. cholerae-like QS circuits and produce CAI-1 and AI-2, we examined the relationship between autoinducers production and DNA uptake....
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...Purified autoinducer molecules activate the comEA gene and DNA uptake by V. cholerae To test directly the role of autoinducers in comEA transcription and DNA uptake, purified CAI-1 and AI-2 where applied to the V. cholerae autoinducer-deficient DcqsA DluxS mutant under the conditions described above....
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