Journal ArticleDOI
Quorum sensing inhibitors: an overview.
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TLDR
This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections and it has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe.About:
This article is published in Biotechnology Advances.The article was published on 2013-03-01. It has received 753 citations till now. The article focuses on the topics: Quorum Quenching & Quorum sensing.read more
Citations
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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
TL;DR: The mechanism of antibiotic resistance in P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections.
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A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation
Colleen T. O'Loughlin,Laura C. Miller,Albert Siryaporn,Knut Drescher,Martin F. Semmelhack,Bonnie L. Bassler +5 more
TL;DR: This study prepares synthetic molecules and analyzes them for inhibition of the Pseudomonas quorum-sensing receptors LasR and RhlR to demonstrate the potential for small-molecule modulators of quorum sensing as therapeutics.
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A critical review of extracellular polymeric substances (EPSs) in membrane bioreactors: Characteristics, roles in membrane fouling and control strategies
Hongjun Lin,Meijia Zhang,Fangyuan Wang,Fangang Meng,Bao-Qiang Liao,Huachang Hong,Jianrong Chen,Weijue Gao +7 more
TL;DR: The fundamentals of EPSs including definitions, compositions and properties, and factors affecting EPSs production and characteristics are summarized and based on which, EPSs control towards membrane fouling mitigation in MBRs are comprehensively discussed.
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Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery
TL;DR: Co-culture studies that aim to increase the diversity of metabolites obtained from microbes, with a special emphasis on the multiple methods of performing co-culture experiments, are focused on.
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Exploiting extracellular polymeric substances (EPS) controlling strategies for performance enhancement of biological wastewater treatments: An overview.
Yahui Shi,Jinhui Huang,Guangming Zeng,Yanling Gu,Chen Yaoning,Yi Hu,Bi Tang,Jianxin Zhou,Ying Yang,Lixiu Shi +9 more
TL;DR: Special emphasis is laid on EPS controlling strategies which would have the great potential in promoting microbial aggregates performance and in alleviating membrane fouling, including limitation strategies and elevation strategies which have been confirmed to be feasible and promising to enhance system performance.
References
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Journal ArticleDOI
Quorum Sensing in Bacteria
TL;DR: The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity.
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QUORUM SENSING: Cell-to-Cell Communication in Bacteria
TL;DR: This review focuses on the architectures of bacterial chemical communication networks; how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Stephen D. Bentley,Keith F. Chater,Ana Cerdeño-Tárraga,Gregory L. Challis,Gregory L. Challis,Nicholas R. Thomson,Keith D. James,David Harris,Michael A. Quail,H. M. Kieser,D. Harper,Alex Bateman,Steve D.M. Brown,Govind Chandra,Carton W. Chen,Mark O. Collins,Ann Cronin,Andrew G. Fraser,Arlette Goble,J. Hidalgo,T. Hornsby,S. Howarth,Chih-Hung Huang,Tobias Kieser,L. Larke,Lee Murphy,Karen Oliver,Susan O'Neil,Ester Rabbinowitsch,Marie-Adèle Rajandream,Kim Rutherford,Simon Rutter,Kathy Seeger,David L. Saunders,Sarah Sharp,R. Squares,S. Squares,K. Taylor,T. Warren,Andreas Wietzorrek,John Woodward,Bart Barrell,Julian Parkhill,David A. Hopwood +43 more
TL;DR: The 8,667,507 base pair linear chromosome of Streptomyces coelicolor is reported, containing the largest number of genes so far discovered in a bacterium.
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Probiotic Bacteria as Biological Control Agents in Aquaculture
TL;DR: This review describes the state of the art of probiotic research in the culture of fish, crustaceans, mollusks, and live food, with an evaluation of the results obtained so far.
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Persister cells, dormancy and infectious disease
TL;DR: The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.