Journal ArticleDOI
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.
Ying Qing,Ying Qing,Lei Dong,Lei Gao,Lei Gao,Chenying Li,Chenying Li,Yangchan Li,Yangchan Li,Li Han,Li Han,Emily Prince,Brandon Tan,Xiaolan Deng,Collin Wetzel,Chao Shen,Min Gao,Min Gao,Zhenhua Chen,Wei Li,Bin Zhang,Bin Zhang,Daniel Braas,Johanna ten Hoeve,Gerardo Javier Sanchez,Huiying Chen,Lai N. Chan,Lai N. Chan,Chun-Wei Chen,Chun-Wei Chen,David K. Ann,Lei Jiang,Markus Müschen,Markus Müschen,Markus Müschen,Guido Marcucci,Guido Marcucci,David R. Plas,Zejuan Li,Rui Su,Jianjun Chen,Jianjun Chen +41 more
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TLDR
This paper showed that R-2-hydroxyglutarate (R-2HG) effectively attenuates aerobic glycolysis, a hallmark of cancer metabolism, in (R 2HG-sensitive) leukemia cells, but not in normal CD34+ hematopoietic stem/progenitor cells.About:
This article is published in Molecular Cell.The article was published on 2021-03-04. It has received 124 citations till now. The article focuses on the topics: PFKP & Anaerobic glycolysis.read more
Citations
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Journal ArticleDOI
FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development
Jiangbo Wei,Xianbin Yu,Lei Yang,Xuelian Liu,Boyang Gao,Boxian Huang,Xiaoyang Dou,Jun Liu,Zhongyu Zou,Xiaolong Cui,Li-Sheng Zhang,Xingsen Zhao,Qinzhe Liu,P. Cody He,Caraline Sepich-Poore,Nicole Zhong,Wenqiang Liu,Yanhe Li,Xiaochen Kou,Yanhong Zhao,You Wu,Xuejun Cheng,Chuan Chen,Yiming An,Xue Dong,Huanyu Wang,Q. L. Shu,Ziyang Hao,Tao Duan,Yu-Ying He,Xuekun Li,Shaorong Gao,Yawei Gao,Chuan He +33 more
TL;DR: Wei et al. as mentioned in this paper showed that FTO mediates m6A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA abundance and the local chromatin state, which in turn modulates the transcription of LINE1-containing genes.
Journal ArticleDOI
YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma.
Rui-Chao Chai,Yu-Zhou Chang,Xin Chang,Bo Pang,Song Yuan An,Kenan Zhang,Yuanhao Chang,Tao Jiang,Yongzhi Wang +8 more
TL;DR: In this paper, the role and mechanism of the RNA N6,2′-O-dimethyladenosine (m6A) reader, YTH N6-methyladenosines RNA binding protein 2 (YTHDF2), in regulating the malignant progression of gliomas was investigated.
Journal ArticleDOI
Insights into N6-methyladenosine and programmed cell death in cancer
Li Liu,Hui Xi Li,Dingyu Hu,Yanyan Wang,Wen-Hai Shao,Jing Zhong,Shudong Yang,Jing Liu,Ji Zhang +8 more
TL;DR: Wang et al. as mentioned in this paper focused on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer.
Journal ArticleDOI
Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11
Zhuoyang Fan,Guowei Yang,Wei Zhang,Qian Liu,Guangqin Liu,Pingping Liu,Ligang Xu,Jian-hua Wang,Zhiping Yan,Hong Han,Rong Liu,Minfeng Shu +11 more
TL;DR: Wang et al. as mentioned in this paper used RT-qPCR and Western blot to evaluate METTL14 expression in hypoxic HCC cells and identified the HIF-1α /METTL14/YTHDF2/SLC7A11 axis as a potential therapeutic target for the HCC interventional embolization treatment.
Journal ArticleDOI
Insights into N6-methyladenosine and programmed cell death in cancer
Li Liu,Hui Xi Li,Dingyu Hu,Yanyan Wang,Wenjun Shao,Jing Zhong,Shudong Yang,Jing Liu,Ji Zhang +8 more
TL;DR: Wang et al. as mentioned in this paper focused on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin,Carrie A. Davis,Felix Schlesinger,Jorg Drenkow,Chris Zaleski,Sonali Jha,Philippe Batut,Mark Chaisson,Thomas R. Gingeras +8 more
TL;DR: The Spliced Transcripts Alignment to a Reference (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequential maximum mappable seed search in uncompressed suffix arrays followed by seed clustering and stitching procedure outperforms other aligners by a factor of >50 in mapping speed.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
KEGG: Kyoto Encyclopedia of Genes and Genomes
Minoru Kanehisa,Susumu Goto +1 more
TL;DR: The Kyoto Encyclopedia of Genes and Genomes (KEGG) as discussed by the authors is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules.
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