Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
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"Rad51-mediated replication fork rev..." refers background in this paper
...…effects of PARP inhibitors on several chemotherapeutic treatments (Rouleau et al., 2010; Ray Chaudhuri et al., 2012) and may also provide alternative mechanistic explanations for the observed synthetic lethality of PARP inhibition and HR defects (Farmer et al., 2005; Neelsen and Lopes, 2015)....
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"Rad51-mediated replication fork rev..." refers background in this paper
...Excess ssDNA at replication forks has been linked to ATR activation (Zou and Elledge, 2003), whereas the formation of a new DNA end at regressed arms may potentially activate ATM in the absence of DSBs....
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...been linked to excess ssDNA at RIs (Zou and Elledge, 2003)....
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...Structural determinants of ATR and ATM activation upon genotoxic treatments in human cells Activation of the ATR-mediated replication checkpoint has been linked to excess ssDNA at RIs (Zou and Elledge, 2003)....
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...Very similar observations on ssDNA accumulation at replication intermediates (RIs) were made on the untransformed human epithelial cell line RPE-1 treated with a subset of the genotoxic agents (Fig....
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...Overall, ATR activation in our experimental conditions does not directly mirror the extent of replication interference, nor the amount of ssDNA detected at RIs (Table 1), and likely reflects yet-undefined signaling determinants that escape systematic cell-based and single-molecule analyses....
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"Rad51-mediated replication fork rev..." refers background in this paper
...It is likely that the length of these ssDNA regions reflects how strongly each treatment interferes with in genome stability and cancer (León-Ortiz et al., 2014; Zeman and Cimprich, 2014; Neelsen and Lopes, 2015)....
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"Rad51-mediated replication fork rev..." refers background in this paper
...RAD51, which then drives homology-directed strand invasion (Symington and Gautier, 2011)....
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