Journal ArticleDOI
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.
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TLDR
Recent advances in understanding of how these factors mediate checkpoint responses and act in the HR repair process are discussed, including potential functional similarities with the BRCA2 tumour suppressor and links between RAD51 paralog deficiencies and tumorigenesis triggered by genome instability.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2011-10-01. It has received 255 citations till now. The article focuses on the topics: DNA repair & RAD51.read more
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Journal ArticleDOI
RAD51B in Familial Breast Cancer
Liisa M. Pelttari,Sofia Khan,Mikko Vuorela,Johanna I. Kiiski,Sara Vilske,Viivi Nevanlinna,Salla Ranta,Johanna Schleutker,Johanna Schleutker,Johanna Schleutker,Robert Winqvist,Anne Kallioniemi,Thilo Dörk,Natalia Bogdanova,Jonine Figueroa,Paul D.P. Pharoah,Marjanka K. Schmidt,Alison M. Dunning,Montserrat Garcia-Closas,Manjeet K. Bolla,Joe Dennis,Kyriaki Michailidou,Qin Wang,John L. Hopper,Melissa C. Southey,Efraim H. Rosenberg,Peter A. Fasching,Peter A. Fasching,Matthias W. Beckmann,Julian Peto,Isabel dos-Santos-Silva,Elinor J. Sawyer,Ian Tomlinson,Barbara Burwinkel,Barbara Burwinkel,Harald Surowy,Harald Surowy,Pascal Guénel,Thérèse Truong,Stig E. Bojesen,Stig E. Bojesen,Børge G. Nordestgaard,Børge G. Nordestgaard,Javier Benitez,Anna González-Neira,Susan L. Neuhausen,Hoda Anton-Culver,Hermann Brenner,Volker Arndt,Alfons Meindl,Rita K. Schmutzler,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Annika Lindblom,Sara Margolin,Arto Mannermaa,Jaana M. Hartikainen,Georgia Chenevix-Trench,kConFab,kConFab,Aocs Investigators,Laurien Van Dyck,Hilde Janssen,Hilde Janssen,Jenny Chang-Claude,Anja Rudolph,Paolo Radice,Paolo Peterlongo,Emily Hallberg,Janet E. Olson,Janet E. Olson,Graham G. Giles,Graham G. Giles,Roger L. Milne,Christopher A. Haiman,Fredrick Schumacher,Jacques Simard,Martine Dumont,Martine Dumont,Vessela N. Kristensen,Vessela N. Kristensen,Anne Lise Børresen-Dale,Wei Zheng,Alicia Beeghly-Fadiel,Mervi Grip,Mervi Grip,Irene L. Andrulis,Gord Glendon,Peter Devilee,Caroline Seynaeve,Maartje J. Hooning,Margriet Collée,Angela Cox,Simon S. Cross,Mitul Shah,Robert Luben,Ute Hamann,Ute Hamann,Diana Torres,Anna Jakubowska,Jan Lubinski,Fergus J. Couch,Drakoulis Yannoukakos,Nick Orr,Anthony J. Swerdlow,Hatef Darabi,Jingmei Li,Kamila Czene,Per Hall,Douglas F. Easton,Johanna Mattson,Carl Blomqvist,Kristiina Aittomäki,Heli Nevanlinna +115 more
TL;DR: It is suggested that loss-of-function mutations in RAD 51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.
Journal ArticleDOI
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Ralph Zellweger,Damian Dalcher,Karun Mutreja,Matteo Berti,Jonas A. Schmid,Raquel Herrador,Alessandro Vindigni,Massimo Lopes +7 more
TL;DR: Genotoxic treatments in human cells consistently induce uncoupling of replication forks and their remodeling into four-way junctions by the RAD51 recombinase.
Journal ArticleDOI
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
Christian Bassi,Jason Ho,Tharan Srikumar,Rjo J. O. Dowling,Chiara Gorrini,Sj J. Miller,Tw W. Mak,Tw W. Mak,Bg G. Neel,Bg G. Neel,Bg G. Neel,Brian Raught,Brian Raught,Vuk Stambolic,Vuk Stambolic +14 more
TL;DR: It is demonstrated that SUMOylation (SUMO, small ubiquitin-like modifier) of PTEN controls its nuclear localization and may have implications for individualized therapy for patients with PTEN-deficient tumors.
Journal ArticleDOI
Characterization of HPV and host genome interactions in primary head and neck cancers.
Michael Parfenov,Chandra Sekhar Pedamallu,Nils Gehlenborg,Nils Gehlenborg,Samuel S. Freeman,Ludmila Danilova,Christopher A. Bristow,Semin Lee,Angela Hadjipanayis,Elena Ivanova,Matthew D. Wilkerson,Alexei Protopopov,Lixing Yang,Sahil Seth,Xingzhi Song,Jiabin Tang,Xiaojia Ren,Jianhua Zhang,Angeliki Pantazi,Netty Santoso,Andrew Wei Xu,Harshad S. Mahadeshwar,D Wheeler,Robert I. Haddad,Joonil Jung,Akinyemi I. Ojesina,Natalia Issaeva,Wendell G. Yarbrough,D. Neil Hayes,Jennifer R. Grandis,Adel K. El-Naggar,Matthew Meyerson,Peter J. Park,Lynda Chin,Jon G. Seidman,Peter S. Hammerman,Raju Kucherlapati,Adrian Ally,Miruna Balasundaram,Inanc Birol,Reanne Bowlby,Yaron S.N. Butterfield,Rebecca Carlsen,Dean Cheng,Andy Chu,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Harshad S. Mahadeshwar,Psalm Haseley,Dong Zeng,Christopher A. Bristow,Angela Hadjipanayis,Jonathan G. Seidman,Rehan Akbani,Tod D. Casasent,Wen-Bin Liu,Yiling Lu,Gordon B. Mills,Thomas C. Motter,John N. Weinstein,Lixia Diao,Jing Wang,You Hong Fan,Jinze Liu,Kai Wang,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Elizabeth Buda,Katherine A. Hoadley,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Patrick K. Kimes,James Stephen Marron,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Joel S. Parker,Charles M. Perou,Jan F. Prins,Jeffrey Roach,Yan Shi,Janae V. Simons,Darshan Singh,Mathew G. Soloway,Donghui Tan,Umadevi Veluvolu,Vonn Walter,Scot Waring,Junyuan Wu,Ni Zhao,Andrew D. Cherniack,Aaron D. Tward,Gordon Saksena,Scott L. Carter,Travis I. Zack,Steven E. Schumacher,Rameen Beroukhim,Juok Cho,Gad Getz,Michael S. Noble,Daniel DiCara,Hailei Zhang,David I. Heiman,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Michael S. Lawrence,Carrie Sougnez,Lee Lichtenstein,Kristian Cibulskis,Eric S. Lander,Stacey Gabriel,Donna M. Muzny,Harshavardhan Doddapaneni,Christie Kovar,Jeffrey S. Reid,Donna Morton,Yi Han,Walker Hale,Hsu Chao,Kyle Chang,Jennifer Drummond,Richard A. Gibbs,Nipun Kakkar,David A. Wheeler,Liu Xi,Giovanni Ciriello,Marc Ladanyi,William Lee,Ricardo Ramirez,Chris Sander,Ronglai Shen,Rileen Sinha,Nils Weinhold,Barry S. Taylor,B. Arman Aksoy,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,Boris Reva,Nikolaus Schultz,S. Onur Sumer,Yichao Sun,Timothy M. Chan,Luc G. T. Morris,Joshua M. Stuart,Stephen C. Benz,Sam Ng,Christopher C. Benz,Christina Yau,Stephen B. Baylin,Leslie Cope,James G. Herman,Moiz S. Bootwalla,Dennis T. Maglinte,Peter W. Laird,Timothy J. Triche,Daniel J. Weisenberger,David Van Den Berg,Nishant Agrawal,Justin A. Bishop,Paul C. Boutros,Jeff Bruce,Lauren Averett Byers,Joseph A. Califano,Thomas E. Carey,Zhong Chen,Hui Cheng,Simion I. Chiosea,Ezra E.W. Cohen,Brenda Diergaarde,Ann Marie Egloff,Robert L. Ferris,Mitchell J. Frederick,Yan Guo,Thomas M. Harris,Angela By Hui,J. Jack Lee,Scott M. Lippman,Fei-Fei Liu,Jonathan B. McHugh,Jeffrey N. Myers,Patrick Kwok Shing Ng,Bayardo Perez-Ordonez,Curtis R. Pickering,Michael B. Prystowsky,Marjorie Romkes,Anthony Saleh,Maureen A. Sartor,Raja R. Seethala,Tanguy Y. Seiwert,Han Si,Carter Van Waes,Daryl Waggott,Maciej Wiznerowicz,Wendell G. Yarbrough,Jiexin Zhang,Zhixiang Zuo,Ken Burnett,Daniel Crain,Johanna Gardner,Kevin Lau,David Mallery,Scott J. Morris,Joseph Paulauskis,Robert Penny,Candance Shelton,Troy Shelton,Mark E. Sherman,Peggy Yena,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Hollie A. Harper,Tara M. Lichtenberg,Nilsa C. Ramirez,Lisa Wise,Erik Zmuda,Julien Baboud,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David A. Pot,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Robert A. Burton,Tanja M. Davidsen,John A. Demchok,Greg Eley,Martin L. Ferguson,Kenna R. Mills Shaw,Bradley A. Ozenberger,Margi Sheth,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Charles Saller,Katherine Tarvin,Chu Chen,Roni J. Bollag,Paul M. Weinberger,Wojciech Golusiński,Paweł Golusiński,Matthiew Ibbs,Konstanty Korski,Andrzej Mackiewicz,Wiktoria Maria Suchorska,Bartosz Szybiak,Erin Curley,Christina Beard,Colleen Mitchell,George E. Sandusky,Julie Ahn,Zubair Khan,Jonathan M. Irish,John W.F. Waldron,Sophie C. Egea,Carmen Gomez-Fernandez,Lynn M. Herbert,Carol R. Bradford,Douglas B. Chepeha,Andrea Haddad,Tamara R. Jones,Christine M. Komarck,Mayya Malakh,Jeffrey S. Moyer,Ariane Nguyen,Lisa A. Peterson,Mark E. Prince,Laura S. Rozek,Evan G. Taylor,Heather M. Walline,Gregory T. Wolf,Lori Boice,Bhishamjit S. Chera,William K. Funkhouser,Margaret L. Gulley,Trevor Hackman,Michele C. Hayward,Mei Huang,W. Kimryn Rathmell,Ashley H. Salazar,William W. Shockley,Carol G. Shores,Leigh B. Thorne,Mark C. Weissler,Sylvia Wrenn,Adam M. Zanation,Brandee T. Brown,Michelle Q. Pham +314 more
TL;DR: A cohort of 279 head and neck cancers with next generation RNA and DNA sequencing is profiled to provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viraloncogenesis.
Journal ArticleDOI
Hereditary breast and ovarian cancer: new genes in confined pathways
TL;DR: HBOC genes are examined, focusing on their role in genome maintenance, the possibilities for functional testing of putative causal variants and the clinical application of new HBOC genes in cancer risk management and treatment decision-making.
References
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