Journal ArticleDOI
Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89.
Michael Bamberg,R.-D. Kortmann,Gabriele Calaminus,Gerd Becker,Christoph Meisner,Dieter Harms,Ulrich Göbel +6 more
Reads0
Chats0
TLDR
Radiotherapy directed toward the craniospinal axis or tumor site alone at decreased dose levels is effective and further attempts to decrease total doses are justified to reduce the risk of late side effects.Abstract:
PURPOSE: A multicenter prospective trial was conducted (Maligue Keimzelltumoren [MAKEI] 83/86/89) to assess outcome in intracranial germinoma after treatment with radiotherapy alone at reduced doses. PATIENTS AND METHODS: Between 1983 and 1993, 60 patients with histologically (n = 58) or cytologically (n = 2) confirmed germinoma were enrolled onto the study. Patients received radiotherapy alone (craniospinal axis/local boost). In the MAKEI 83/86 study (involving 11 patients), the dose to the craniospinal axis was 36 Gy and the dose to the tumor region was 14 Gy. In the MAKEI 89 study (involving 49 patients), doses were 30 and 15 Gy, respectively. RESULTS: Median patient age was 13 years (range, 6 to 31 years). Complete remission was achieved in all patients. The estimated (Kaplan-Meier) 5-year relapse-free survival rate was 91.0% ± 3.9% at a mean follow-up of 59.5 months (range, 3 to 180 months); the estimated overall survival rate was 93.7% ± 3.6%. Relapse occurred in five patients 10 to 33 months (mean,...read more
Citations
More filters
Journal ArticleDOI
Pediatric central nervous system germ cell tumors: a review.
TL;DR: Central nervous system (CNS) germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors and encompass a wide pathologic spectrum and treatment and prognosis differ greatly between groups.
Journal ArticleDOI
Germ-cell tumors in childhood and adolescence
TL;DR: The completeness of the primary tumor resection according to oncological standards has been established as the most powerful prognostic parameter superior to tumor marker levels or primary site of the tumor.
Journal ArticleDOI
SIOP CNS GCT 96: Final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease
Gabriele Calaminus,Rolf D. Kortmann,Jennifer Worch,James Nicholson,Claire Alapetite,Maria Luisa Garrè,Catherine Patte,Umberto Ricardi,Frank Saran,Didier Frappaz +9 more
TL;DR: Localized germinoma can be treated with reduced dose CSI alone or with chemotherapy and reduced-field radiotherapy, and the pattern of relapse suggests inclusion of ventricles in the radiation field.
Journal ArticleDOI
Radiotherapy of localised intracranial germinoma: time to sever historical ties?
TL;DR: This work challenges the consensus that craniospinal radiotherapy is the best treatment for localised germinomas and concludes that reduced-volume radiotherapy plus boost should replace craniographic radiotherapy when a radiotherapy-only approach is used.
Journal ArticleDOI
Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors.
TL;DR: Investigation of chemotherapy followed by low-dose involved-field radiotherapy for the treatment of intracranial germ cell tumors found disease-related, overall, and relapse-free survival rates at 5 years were 100%, 93%, and 69% for all patients.
References
More filters
Journal ArticleDOI
Whole-Brain Irradiation and Decline in Intelligence: The Influence of Dose and Age on IQ Score
Jeffrey H. Silber,Jerilynn Radcliffe,Virginia C. Peckham,Giorgio Perilongo,Priya S. Kishnani,Moshe Fridman,Joel W. Goldwein,Anna T. Meadows +7 more
TL;DR: One can forecast final IQ score based on the initial IQ score, dose of irradiation, and age at time of irradiations, and the findings should aid in the selection of appropriate therapy when whole-brain irradiation is needed.
Journal ArticleDOI
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study.
Casilda Balmaceda,Glenn Heller,Marc K. Rosenblum,Blanca Diez,Judith G. Villablanca,Stewart J. Kellie,P Maher,V Vlamis,Russell W. Walker,Steven A. Leibel,Jonathan L. Finlay +10 more
TL;DR: Chemotherapy-only regimens for CNS GCT, although encouraging, should continue to be used only in the setting of formal clinical trials.
Journal ArticleDOI
Pineal region tumors in children.
TL;DR: The authors believe that the preferred treatment for pineal region tumors in children requires definitive surgery with a histological diagnosis and that a conservative approach consisting of shunting and radiation therapy no longer seems to be appropriate.
Journal ArticleDOI
The long‐term effects of cranial irradiation on the central nervous system
TL;DR: Radiation effects on intellect, endocrine function, and oncogenesis are emphasized and recommendations for baseline and longitudinal evaluations of children with brain tumors are suggested.
Journal ArticleDOI
Midline pineal tumors and suprasellar germinomas: highly curable by irradiation.
TL;DR: Sixty-one patients with midline pineal tumors and 16 patients with suprasellar germinomas were treated with surgical decompression and relatively high-dose radiotherapy of the primary site, and there were no long-term complications.