Radical operation for carcinoma of the vulva
01 Nov 1970-British Journal of Obstetrics and Gynaecology (Blackwell Publishing Ltd)-Vol. 77, Iss: 11, pp 1037-1040
About: This article is published in British Journal of Obstetrics and Gynaecology.The article was published on 1970-11-01. It has received 106 citations till now.
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892 citations
TL;DR: The high antibacterial activity of manuka honey was in many cases due entirely to this non‐peroxide component.
Abstract: To assess the variation in antibacterial activity of honey a survey was carried out on 345 samples of unpasteurized honey obtained from commercial apiarists throughout New Zealand. Most of the honeys were considered to be monofloral, from 26 different floral sources. The honeys were tested against Staphylococcus aureus in an agar well diffusion assay, with reference to phenol as a standard. Antibacterial activity was found to range from the equivalent of less than 2% (w/v) phenol to 58% (w/v) phenol, with a median of 13.6 and a standard deviation of 12.5. Neither the age of the honey samples nor whether they had been processed by the apiarist was associated with lower activity. However, the difference between floral sources in the antibacterial activity was very highly significant. Kanuka (Kunzea ericoides (A. Rich.) J. Thompson. Family: Myrtaceae), manuka (Leptospermum scoparium J. R. et G. Forst. Family: Myrtaceae), ling heather (Calluna vulgaris (L.) Hull. Family: Ericaceae) and kamahi (Weinmannia racemosa Linn. f. Family: Cunoniaceae) were shown to be sources likely to give honey with high antibacterial activity. When antibacterial activity was assayed with catalase added to remove hydrogen peroxide, most of the honeys showed no detectable antibacterial activity. Only manuka and vipers bugloss (Echium vulgare L. Family: Boraginaceae) honeys showed this type of activity in a significant proportion of the samples. The high antibacterial activity of manuka honey was in many cases due entirely to this non-peroxide component.
580 citations
TL;DR: In this article, the authors established a solid platform of analytical information for the definition/standardization of the antioxidant properties of honey, using a battery of spectrophotometric tests: Folin-Ciocalteu assay for phenol content, ferric reducing antioxidant power (FRAP) for total antioxidant activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay for antiradical activity, absorbance:450 (ABS 450 ) for color intensity and one fluorimetric method: ORAC,
536 citations
TL;DR: Honey debrided wounds rapidly, replacing sloughs with granulation tissue, and promoted rapid epithelialization, and absorption of oedema from around the ulcer margins.
Abstract: Fifty-nine patients with wounds and ulcers most of which (80 per cent) had failed to heal with conventional treatment were treated with unprocessed honey. Fifty-eight cases showed remarkable improvement following topical application of honey. One case, later diagnosed as Buruli ulcer, failed to respond. Wounds that were sterile at the outset, remained sterile until healed, while infected wounds and ulcer became sterile within 1 week of topical application of honey. Honey debrided wounds rapidly, replacing sloughs with granulation tissue. It also promoted rapid epithelialization, and absorption of oedema from around the ulcer margins.
414 citations
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01 Jan 1996
TL;DR: Value-added products from beekeeping as mentioned in this paper, value added products from bees, Value-added items from bees from bee-keeping, value-added product from bees and bees.
Abstract: Value-added products from beekeeping , Value-added products from beekeeping , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
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References
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TL;DR: In this paper, an analysis of 50 patients with invasive carcinoma of the vulva seen in the Department of Obstetrics and Gynecology at the University of Miami School of Medicine, Jackson Memorial Hospital, from January 1, 1955, to August 1, 1965, is presented.
Abstract: SUMMARY
1
An analysis of 50 patients with invasive carcinoma of the vulva seen in the Department of Obstetrics and Gynecology at the University of Miami School of Medicine, Jackson Memorial Hospital, from January 1, 1955, to August 1, 1965, is presented.
2
Predisposing conditions such as leukoplakia (6 patients), granulomatous disease (2 patients) and syphilis (2 patients) were noted in 10 patients (20%). Two patients were pregnant.
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Use of the Collins test in patients with leukoplakia and other lesions of the vulva is suggested for the purpose of selecting optimum biopsy sites.
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Radical vulvectomy, bilateral groin and/or pelvic lymphadenectomy was performed in 30 patients; in addition to ilio-femoral lymphadenectomy, pelvic exenteration was performed in 3 patients. There was one death attributed to the operation (3%).
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Significant post-operative complications were wound breakdown in 30 (91%), rupture of the femoral artery 3 (9%), rupture of the femoral vein 1 (3%), and persistent leg oedema in 3 (9%).
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No meaningful 5-year survival rate statistics are available, but 1-year survival rates were as follows: 4 of 11 patients with positive lymph nodes, and 16 of 22 patients with negative lymph nodes. For 40 patients with McKelvey 1-3 lesions the 1-year survival was 65%. Of 10 patients treated palliatively only, 1 survived the first year.
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Lymphography was useful in predicting nodal metastases in 17 of 20 patients (85%).
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No patient with negative groin nodes had positive pelvic nodes and so the wisdom of “routine” pelvic lymphade-nectomy is in doubt.
8 citations