Radiomics: the bridge between medical imaging and personalized medicine
Summary (1 min read)
Introduction
- The addition of hydroxylamine to aldehydes and ketones is a well known reaction, indeed the sharp melting points of the highly crystalline oxime derivatives have traditionally been used to characterise the parent carbonyl compounds.
- A higher stratum of control over the participating centres invokes the employment of remote space filling substituents to minimise the spatial disparity between the reactants.
- Significantly, reactions which do not otherwise take place are shown to proceed well when steric buttresses are incorporated into the ortho-position/s of a benzene ring (positions analogous to R4 and R5).
- The article does not cite any examples where bulky substituents, in positions other than ortho (e.g. R1 and R2), are able to act as predictable steric buttresses.
Results and discussion
- The preparation of the targeted carbonyl substrates 1a–c and 1j–n involves as the key step coupling of the amines 6 with the appropriate acyl halides 7; oxidation of the resulting oamidobenzyl alcohol 8 furnishes the desired aldehydes (Scheme 2).
- The aldehyde 1j is a tertiary amide analogue of 1a and it may be anticipated that the additional substitution on the olefinic tether (R2 = Me) will influence its reactivity.
- Increasing the reaction temperature to 80 8C failed to promote further reaction, however heating a solution of the oxime in xylene at reflux (140 8C) leads to quantitative conversion to the tricyclic adduct 5k.
Conclusions
- The influence of the space filling substituents, R1, R2 and R4 and of the electronic nature of R3 on the course of the reaction of the carbonyl compounds 1 with NH2OH, is quite striking.
- In those cases where a sterically bulky group (R4≠ H) is positioned ortho to the carbonyl functionality tricyclic isoxazolobenzodiazepinones result, this tricyclic system also arises if the amide nitrogen is tertiary (R2 ≠ H).
- In no case is an APT reaction observed when the olefinic moiety is substituted with a phenyl group, one explanation considers that this substituent has no significant influence on the electrophilicity of the pendant olefinic centre and therefore no ability to promote the internal cyclisation reaction.
- That the substituent R2 may have both a steric and electronic role in facilitating tricycle formation cannot be dismissed.
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References
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Frequently Asked Questions (19)
Q2. What have the authors contributed in "Radiomics: the bridge between medical imaging and personalized medicine" ?
Herein, the authors describe the process of radiomics, its pitfalls, challenges, opportunities, and its capacity to improve clinical decision making, emphasizing the utility for patients with cancer. Herein, the authors provide guidance for investigations to meet this urgent need in the field of radiomics.
Q3. What are the future works in "Radiomics: the bridge between medical imaging and personalized medicine" ?
Picture archiving and radiomics knowledge systems ( PARKS ) of the future will identify, segment, and extract features from regions of interest. If previous images associated with the same patient are accessible, the earlier identified regions of interest will be automatically identified by the PARKS software. Quantitative image features that are uploaded to a shared database and compared with previous images will be automatically extracted by the PARKS to enhance CDSS for diagnosis, prognosis, and treatment, resulting in improved personalization and precision medicine ( FIG. 7 ).
Q4. What is the promising research area in oncology?
In the field of oncology, a promising research area is that of biomarkers — in particular, biomarkers for immunotherapy and imaging biomarkers90,91.
Q5. what is the need for standardized methodology in tumor texture analysis?
The effect of SUV discretization in quantitative FDG-PET radiomics: the need for standardized methodology in tumor texture analysis.
Q6. What is the current method of quantification of the radiosensitivity of human tumours?
The quantification of the radiosensitivity of human tumours is presently performed on the basis of the ex vivo tumour survival fraction, and the detection of unrepaired DNA double-strand breaks82,83.
Q7. What is the way to achieve a holistic model?
To achieve holistic models, features beyond radiomics (such as data from clinical records, data obtained during treatment or biological and/or genetic) should also be incorporated.
Q8. What are the main benefits of a standardized RLHC?
In addition, universal streamlined solutions through advanced information communication technologies have been central to the realization of this endeavor, readily facilitating synchronized RLHC in each centre without inclusion of sensitive data, which overcomes the classic barriers to data sharing.
Q9. What is the purpose of phantom studies?
In essence, phantom studies provide a risk-mitigation strategy to help navigate from the current clinical imaging scenario to the desired optimal imaging scenario.
Q10. Why should a radiomic study incorporate reproducibility assessments?
Radiomic studies should incorporate reproducibility assessments owing to the beneficial ethical, economic and logistical effects they have (such asinforming power calculations and required samples sizes, multicentric trial duration and trial cost).
Q11. What is the way to evaluate the features of a radiomics dataset?
Feature selection should be data-driven owing to the vast in- human range of possible radiomics features; such analysis should be performed in a robust and transparent manner.
Q12. What drives the research and clinical communities?
A pressing need to embrace knowledge and data-sharing technology106, which transcends institutional and national boundaries107, drives both the research and clinical communities.
Q13. What is the effect of IGF-1R inhibition on radiosensitivity?
85. Chitnis, M. M. et al. IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Q14. What can be done to improve the quality of radiomics?
Although the minute technical details of radiomics are tedious, they can greatly influence robustness, generalizability, and confound meta- analyses.
Q15. What are some examples of robust features that can be observed?
Examples that enable robust features to be observed21 include: evaluation by multiple clinicians, perturb segmentations with noise, combination of diverse algorithms, or use different stages of the breathing cycle.
Q16. What is the main advantage of using the ontology terms?
Exploiting this technique, the ontology terms serve as a common reference for the data at each institutional site, permitting a unified process for information retrieval enabled by a semantic gateway to the data.
Q17. What is the main reason why these approaches have been undermined?
these approaches have been undermined by the presence of substantial experimental variability rather than by the existence of interpatient variations in radiosensitivity.
Q18. How can groups of highly correlated radiomics features be identified?
Groups of highly correlated radiomics features can be identified via clustering, and these features can be reduced to single archetypal features per cluster.
Q19. What are the capabilities of the current picture archiving and communication systems?
Such capabilities are on the technological, scientific, and clinical horizons, as most current picture archiving and communication systems have the capability to co-register current images with previous images and perform user-interactive segmentation.