Raising awareness of acute kidney injury: a global perspective of a silent killer
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TLDR
A framework of reference is provided and specific strategies to raise awareness of AKI globally, with the goal to ultimately improve outcomes from this devastating disease, are proposed.About:
This article is published in Kidney International.The article was published on 2013-09-01 and is currently open access. It has received 515 citations till now. The article focuses on the topics: Kidney disease.read more
Citations
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Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
Journal ArticleDOI
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Lakhmir S. Chawla,Rinaldo Bellomo,Azra Bihorac,Stuart L. Goldstein,Edward D. Siew,Sean M. Bagshaw,D B Bittleman,Dinna N. Cruz,Zoltan H. Endre,Robert L. Fitzgerald,Lui G. Forni,Sandra L. Kane-Gill,Eric Hoste,Jay L. Koyner,Kathleen D. Liu,Etienne Macedo,Ravindra L. Mehta,Patrick T. Murray,Mitra K. Nadim,Marlies Ostermann,Paul M. Palevsky,Neesh Pannu,Mitchell H. Rosner,Ron Wald,Alexander Zarbock,Claudio Ronco,John A. Kellum +26 more
TL;DR: The Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients, and makes recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.
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International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology
Ravindra L. Mehta,Jorge Cerdá,Emmanuel A. Burdmann,Marcello Tonelli,Guillermo Garcia-Garcia,Vivekanand Jha,Paweena Susantitaphong,Paweena Susantitaphong,Michael V. Rocco,Raymond Vanholder,Mehmet Sukru Sever,Dinna N. Cruz,Bertrand L. Jaber,Norbert Lameire,Raúl Lombardi,Andrew Lewington,John Feehally,Fredric O. Finkelstein,Nathan W. Levin,Neesh Pannu,Bernadette Thomas,Eliah Aronoff-Spencer,Giuseppe Remuzzi +22 more
TL;DR: The ability to provide lifesaving treatments for AKI provides a compelling argument to consider therapy forAKI as much of a basic right as it is to give antiretroviral drugs to treat HIV in low-resource regions, especially because care needs only be given for a Published Online March 13, 2015 http://dx.doi.org/10.1016/ S0140-6736(15)60126-X
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Global epidemiology and outcomes of acute kidney injury
Eric Hoste,John A. Kellum,Nicholas M. Selby,Alexander Zarbock,Paul M. Palevsky,Sean M. Bagshaw,Stuart L. Goldstein,Jorge Cerdá,Lakhmir S. Chawla +8 more
TL;DR: The global epidemiology of acute kidney injury is described and the influence of modifiable and non-modifiable AKI risk factors, delayed diagnosis, variation in diagnostic criteria and disparities in access to health care are also discussed.
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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
Mei T. Tran,Zsuzsanna K. Zsengellér,Anders H. Berg,Eliyahu V. Khankin,Manoj Bhasin,Wondong Kim,Clary B. Clish,Isaac E. Stillman,S. Ananth Karumanchi,S. Ananth Karumanchi,Eugene P. Rhee,Eugene P. Rhee,Samir M. Parikh +12 more
TL;DR: It is shown that the mitochondrial biogenesis regulator, PGC1α, is a pivotal determinant of renal recovery from injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis, and NAM treatment reverses established ischaemic AKI and also prevented AKI in an unrelated toxic model.
References
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Journal ArticleDOI
KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
Journal ArticleDOI
Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: The Acute Kidney Injury Network (AKI Network) as discussed by the authors is a multidisciplinary collaborative network focused on AKI, which was established to improve care for patients with or at risk for AKI.
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
Journal ArticleDOI
Acute Renal Failure in Critically Ill Patients: A Multinational, Multicenter Study
Shigehiko Uchino,John A. Kellum,Rinaldo Bellomo,Gordon S. Doig,Hiroshi Morimatsu,Stanislao Morgera,Miet Schetz,Ian Tan,Catherine S. C. Bouman,Ettiene Macedo,Noel Gibney,Ashita Tolwani,Claudio Ronco +12 more
TL;DR: In this article, the period prevalence of acute renal failure (ARF) requiring renal replacement therapy (RRT) was found to be between 5% and 6% and was associated with a high hospital mortality rate.
Journal ArticleDOI
Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients
TL;DR: Modest changes in SCr were significantly associated with mortality, LOS, and costs, even after adjustment for age, gender, admission International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis, severity of illness (diagnosis-related group weight), and chronic kidney disease.
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