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Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
Anders G. Olsson,Jjv McMurray,Gudmundur Thorgeirsson,C Spaulding,J Slattery,Kalevi Pyörälä,Ole Faergeman,RA Wright,Kåre Berg,Lars Wilhelmsen,Terje R. Pedersen,Tatu A. Miettinen,Harvey D. White,John Kjekshus,Michael Gnant +14 more
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This article is published in The Lancet.The article was published on 1994-11-18 and is currently open access. It has received 8920 citations till now. The article focuses on the topics: Simvastatin & Statin.read more
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Prediction of Coronary Heart Disease Using Risk Factor Categories
Peter W.F. Wilson,Ralph B. D'Agostino,Daniel Levy,Albert M. Belanger,Halit Silbershatz,William B. Kannel +5 more
TL;DR: A simple coronary disease prediction algorithm was developed using categorical variables, which allows physicians to predict multivariate CHD risk in patients without overt CHD.
Journal ArticleDOI
2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Neil J. Stone,Jennifer G. Robinson,Alice H. Lichtenstein,C. Noel Bairey Merz,Conrad B. Blum,Robert H. Eckel,Anne C. Goldberg,David Lee Gordon,Daniel Levy,Donald M. Lloyd-Jones,Patrick E. McBride,J. Sanford Schwartz,Susan T. Shero,Sidney C. Smith,Karol E. Watson,Peter W.F. Wilson +15 more
TL;DR: Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2 The goals of the …
Journal ArticleDOI
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Scott M. Grundy,James I. Cleeman,C. Noel Bairey Merz,H. Bryan Brewer,Luther T. Clark,Donald B. Hunninghake,Richard C. Pasternak,Sidney C. Smith,Neil J. Stone +8 more
TL;DR: The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C.
Journal ArticleDOI
Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction
TL;DR: It is suggested that diabetic patients without previous myocardial infarction have as high a risk of myocardia infarctions as nondiabetic patients with previous my Cardiac Arrest.
Journal ArticleDOI
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
Mohammad H. Forouzanfar,Lily Alexander,H. Ross Anderson,Victoria F Bachman,Stan Biryukov,Michael Brauer,Richard T. Burnett,Daniel Casey,Daniel Casey,Matthew M Coates,Aaron Cohen,Kristen Delwiche,Kara Estep,Joseph Frostad,K. C. Astha,Hmwe H Kyu,Maziar Moradi-Lakeh,Maziar Moradi-Lakeh,Marie Ng,Erica Leigh Slepak,Bernadette Thomas,Joseph A Wagner,Gunn Marit Aasvang,Cristiana Abbafati,Ayse Abbasoglu Ozgoren,Foad Abd-Allah,Semaw Ferede Abera,Semaw Ferede Abera,Victor Aboyans,Biju Abraham,Jerry Puthenpurakal Abraham,Ibrahim Abubakar,Niveen M E Abu-Rmeileh,Tania C Aburto,Tom Achoki,Ademola Lukman Adelekan,Koranteng Adofo,Arsène Kouablan Adou,Jose C. Adsuar,Ashkan Afshin,Emilie Agardh,Mazin J. Al Khabouri,Faris Lami,Sayed Saidul Alam,Deena Alasfoor,Mohammed I. Albittar,Miguel Angel Alegretti,Alicia Aleman,Zewdie Aderaw Alemu,Rafael Alfonso-Cristancho,Samia Alhabib,Raghib Ali,Mohammed K. Ali,François Alla,Peter Allebeck,Peter J. Allen,Ubai Alsharif,Elena Alvarez,Nelson Alvis-Guzman,Adansi A. Amankwaa,Azmeraw T. Amare,Emmanuel A. Ameh,Omid Ameli,Heresh Amini,Walid Ammar,Benjamin O Anderson,Carl Abelardo T. Antonio,Palwasha Anwari,Solveig A. Cunningham,Johan Ärnlöv,Valentina S. Arsic Arsenijevic,Al Artaman,Rana J. Asghar,Reza Assadi,Lydia S. Atkins,Charles Atkinson,Marco A Avila,Baffour Awuah,Alaa Badawi,Maria Cecilia Bahit,Talal Bakfalouni,Kalpana Balakrishnan,Shivanthi Balalla,Ravi Kumar Balu,Amitava Banerjee,Ryan M Barber,Suzanne Barker-Collo,Simón Barquera,Lars Barregard,Lope H Barrero,Tonatiuh Barrientos-Gutiérrez,Ana Basto-Abreu,Arindam Basu,Sanjay Basu,Mohammed O. Basulaiman,Carolina Batis Ruvalcaba,Justin Beardsley,Neeraj Bedi,Tolesa Bekele,Michelle L. Bell,Corina Benjet,Derrick A Bennett,Habib Benzian,Eduardo Bernabé,Tariku Jibat Beyene,Neeraj Bhala,Ashish Bhalla,Zulfiqar A Bhutta,Boris Bikbov,Aref A. Bin Abdulhak,Jed D. Blore,Fiona M. Blyth,Megan Bohensky,Berrak Bora Basara,Guilherme Borges,Natan M. Bornstein,Dipan Bose,Soufiane Boufous,Rupert R A Bourne,Michael Brainin,Alexandra Brazinova,Nicholas J K Breitborde,Hermann Brenner,Adam D M Briggs,David M. Broday,Peter Brooks,Nigel Bruce,Traolach S. Brugha,Bert Brunekreef,Rachelle Buchbinder,Linh N Bui,Gene Bukhman,Andrew G. M. Bulloch,Michael Burch,Peter Burney,Ismael R. Campos-Nonato,Julio Cesar Campuzano,Alejandra Cantoral,Jack Caravanos,Rosario Cárdenas,Elisabeth Cardis,David O. Carpenter,Valeria Caso,Carlos A Castañeda-Orjuela,Ruben Castro,Ferrán Catalá-López,Ferrán Catalá-López,Fiorella Cavalleri,Alanur Çavlin,Vineet K. Chadha,Jung-Chen Chang,Fiona J Charlson,Honglei Chen,Wanqing Chen,Zhengming Chen,Peggy Pei-Chia Chiang,Odgerel Chimed-Ochir,Rajiv Chowdhury,Costas A. Christophi,Costas A. Christophi,Ting Wu Chuang,Sumeet S. Chugh,Massimo Cirillo,Thomas Claßen,Valentina Colistro,Mercedes Colomar,Samantha M. Colquhoun,Alejandra G. Contreras,Cyrus Cooper,Kimberly Cooperrider,Leslie T. Cooper,Josef Coresh,Karen J. Courville,Michael H. Criqui,Lucía Cuevas-Nasu,James Damsere-Derry,Hadi Danawi,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Paul I. Dargan,Adrian Davis,Dragos Virgil Davitoiu,Anand Dayama,E Filipa de Castro,Vanessa De la Cruz-Góngora,Diego De Leo,Graça Maria Ferreira De Lima,Louisa Degenhardt,Borja del Pozo-Cruz,Robert P. Dellavalle,Kebede Deribe,Sarah Derrett,Don C. Des Jarlais,Muluken Dessalegn,Gabrielle deVeber,Karen Devries,Samath D Dharmaratne,Mukesh Dherani,Daniel Dicker,Eric L. Ding,Klara Dokova,E. Ray Dorsey,Tim Driscoll,Leilei Duan,Adnan M. Durrani,Beth E. Ebel,Richard G. Ellenbogen,Yousef M. Elshrek,Matthias Endres,Sergey Petrovich Ermakov,Holly E. Erskine,Babak Eshrati,Alireza Esteghamati,Saman Fahimi,Emerito Jose A. Faraon,Farshad Farzadfar,Derek F J Fay,Valery L. Feigin,Andrea B. Feigl,Seyed-Mohammad Fereshtehnejad,Alize J. Ferrari,Cleusa P. Ferri,Abraham D. Flaxman,Thomas D. Fleming,Nataliya Foigt,Kyle J Foreman,Urbano Fra Paleo,Richard C. Franklin,Belinda J. Gabbe,Lynne Gaffikin,Emmanuela Gakidou,Amiran Gamkrelidze,Fortuné Gbètoho Gankpé,Ron T. Gansevoort,Francisco A García-Guerra,Evariste Gasana,Johanna M. Geleijnse,Bradford D. Gessner,Peter W. Gething,Katherine B Gibney,Richard F. Gillum,Ibrahim Abdelmageem Mohamed Ginawi,Maurice Giroud,Giorgia Giussani,Shifalika Goenka,Ketevan Goginashvili,Héctor Gómez Dantés,Philimon Gona,Teresita González de Cosío,Dinorah González-Castell,Carolyn C. Gotay,Atsushi Goto,Hebe N. Gouda,Richard L. Guerrant,Harish Chander Gugnani,Francis Guillemin,David Gunnell,Rashmi Gupta,Rajeev Gupta,Reyna A Gutiérrez,Nima Hafezi-Nejad,Holly Hagan,Maria Hagströmer,Yara A. Halasa,Randah R. Hamadeh,Mouhanad Hammami,Graeme J. Hankey,Yuantao Hao,Hilda L Harb,Tilahun Nigatu Haregu,Josep Maria Haro,Rasmus Havmoeller,Simon I. Hay,Mohammad Taghi Hedayati,Ileana Heredia-Pi,Lucia Hernandez,Kyle R. Heuton,Pouria Heydarpour,Martha Híjar,Hans W. Hoek,Howard J. Hoffman,John Hornberger,H. Dean Hosgood,Damian G Hoy,Mohamed Hsairi,Guoqing Hu,Howard Hu,Cheng Huang,John J Huang,Bryan Hubbell,Laetitia Huiart,Abdullatif Husseini,Marissa Iannarone,Kim Moesgaard Iburg,Bulat Idrisov,Nayu Ikeda,Kaire Innos,Manami Inoue,Farhad Islami,Samaya Ismayilova,Kathryn H. Jacobsen,Henrica A. F. M. Jansen,Deborah Jarvis,Simerjot K. Jassal,Alejandra Jáuregui,Sudha Jayaraman,Panniyammakal Jeemon,Paul N Jensen,Vivekanand Jha,Fan Jiang,Guohong Jiang,Ying Jiang,Jost B. Jonas,Knud Juel,Haidong Kan,Sidibe S Kany Roseline,Nadim E. Karam,André Karch,Corine Karema,Ganesan Karthikeyan,Anil Kaul,Norito Kawakami,Dhruv S. Kazi,Andrew H. Kemp,Andre Pascal Kengne,Andre Keren,Yousef Khader,Shams Eldin Ali Hassan Khalifa,Ejaz Ahmad Khan,Young-Ho Khang,Shahab Khatibzadeh,Irma Khonelidze,Christian Kieling,Daniel Kim,Sungroul Kim,Yun Jin Kim,Ruth W Kimokoti,Yohannes Kinfu,Jonas Minet Kinge,Brett M. Kissela,Miia Kivipelto,Luke D. Knibbs,Ann Kristin Knudsen,Yoshihiro Kokubo,M Rifat Kose,Soewarta Kosen,Alexander Kraemer,Michael Kravchenko,Sanjay Krishnaswami,Hans Kromhout,Tiffany Ku,Barthelemy Kuate Defo,Burcu Kucuk Bicer,Ernst J. Kuipers,Chanda Kulkarni,Veena S. Kulkarni,G Anil Kumar,Gene F. Kwan,Taavi Lai,Arjun Lakshmana Balaji,Ratilal Lalloo,Tea Lallukka,Hilton Lam,Qing Lan,Van C. Lansingh,Heidi J. Larson,Anders Larsson,Dennis Odai Laryea,Pablo M. Lavados,Alicia Elena Beatriz Lawrynowicz,Janet L Leasher,Jongmin Lee,James Leigh,Ricky Leung,Miriam Levi,Yichong Li,Yongmei Li,Juan Liang,Xiaofeng Liang,Stephen S Lim,M. Patrice Lindsay,Steven E. Lipshultz,Shiwei Liu,Yang Liu,Belinda K Lloyd,Belinda K Lloyd,Giancarlo Logroscino,Stephanie J. London,Nancy Lopez,Joannie Lortet-Tieulent,Paulo A. Lotufo,Rafael Lozano,Raimundas Lunevicius,Jixiang Ma,Stefan Ma,Vasco Manuel Pedro Machado,Michael F. MacIntyre,Carlos Magis-Rodriguez,Abbas Ali Mahdi,Marek Majdan,Reza Malekzadeh,Srikanth Mangalam,Christopher C. Mapoma,Marape Marape,Wagner Marcenes,David J. Margolis,David J. Margolis,Christopher Margono,Guy B. Marks,Randall V. Martin,Melvin Barrientos Marzan,Mohammad T Mashal,Felix Masiye,Amanda J. Mason-Jones,Kunihiro Matsushita,Richard Matzopoulos,Bongani M. Mayosi,Tasara T. Mazorodze,Abigail C. McKay,Martin McKee,Abigail McLain,Peter A. Meaney,Catalina Medina,Man Mohan Mehndiratta,Fabiola Mejía-Rodríguez,Wubegzier Mekonnen,Yohannes Adama Melaku,Michele Meltzer,Ziad A. Memish,Walter Mendoza,George A. Mensah,Atte Meretoja,Francis Apolinary Mhimbira,Renata Micha,Ted R. Miller,Ted R. Miller,Edward J Mills,Awoke Misganaw,Santosh Mishra,Norlinah Mohamed Ibrahim,K. A. Mohammad,Ali H. Mokdad,Glen Mola,Lorenzo Monasta,Julio Cesar Montañez Hernandez,Marcella Montico,Ami R Moore,Lidia Morawska,Rintaro Mori,Joanna Moschandreas,Wilkister N. Moturi,Dariush Mozaffarian,Ulrich O Mueller,Mitsuru Mukaigawara,Erin C Mullany,Kinnari S. Murthy,Mohsen Naghavi,Ziad Nahas,Aliya Naheed,Kovin Naidoo,Luigi Naldi,Devina Nand,Vinay Nangia,K.M. Venkat Narayan,Denis Nash,Bruce Neal,Chakib Nejjari,Sudan Prasad Neupane,Charles R. Newton,Charles R. Newton,Frida Namnyak Ngalesoni,Jean de Dieu Ngirabega,Grant Nguyen,Nhung T Nguyen,Mark J. Nieuwenhuijsen,Muhammad Imran Nisar,José R Nogueira,Joan M. Nolla,Sandra Nolte,Ole Frithjof Norheim,Rosana E. Norman,Bo Norrving,Luke Nyakarahuka,In-Hwan Oh,Takayoshi Ohkubo,Bolajoko O. Olusanya,Saad B. Omer,John Nelson Opio,Ricardo Orozco,Rodolfo S Pagcatipunan,Amanda W Pain,Jeyaraj D Pandian,Carlo Irwin A. Panelo,Christina Papachristou,Eun-Kee Park,Charles D. H. Parry,Angel J Paternina Caicedo,Scott B. Patten,Vinod K. Paul,Boris I. Pavlin,Neil Pearce,Lilia S Pedraza,Andrea Pedroza,Ljiljana Pejin Stokic,Ayfer Pekericli,David M. Pereira,Rogelio Pérez-Padilla,Fernando Perez-Ruiz,Norberto Perico,Samuel A L Perry,Aslam Pervaiz,Konrad Pesudovs,Carrie Beth Peterson,Max Petzold,Michael R. Phillips,Hwee Pin Phua,Dietrich Plass,Dan Poenaru,Guilherme V. Polanczyk,Suzanne Polinder,Constance D. Pond,C. Arden Pope,Daniel Pope,Svetlana Popova,Farshad Pourmalek,John Powles,Dorairaj Prabhakaran,Noela M Prasad,Dima M. Qato,Amado D Quezada,D. Alex Quistberg,Lionel Racapé,Anwar Rafay,Kazem Rahimi,Vafa Rahimi-Movaghar,Sajjad Ur Rahman,Murugesan Raju,Ivo Rakovac,Saleem M Rana,Mayuree Rao,Homie Razavi,K. Srinath Reddy,Amany H Refaat,Amany H Refaat,Jürgen Rehm,Giuseppe Remuzzi,Antônio Luiz Pinho Ribeiro,Patricia M. Riccio,Lee Richardson,Anne M. Riederer,Margaret Robinson,Anna Roca,Alina Rodriguez,David Rojas-Rueda,Isabelle Romieu,Luca Ronfani,Robin Room,Nobhojit Roy,George Mugambage Ruhago,Lesley Rushton,Nsanzimana Sabin,Ralph L. Sacco,Sukanta Saha,Ramesh Sahathevan,Mohammad Ali Sahraian,Joshua A. Salomon,Deborah Salvo,Uchechukwu K.A. Sampson,Juan Sanabria,Juan Sanabria,Luz Maria Sanchez,Tania G Sánchez-Pimienta,Lidia Sanchez-Riera,Logan Sandar,Itamar S. Santos,Amir Sapkota,Maheswar Satpathy,James E. Saunders,Monika Sawhney,Mete Saylan,Peter Scarborough,Jürgen C Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,David C. Schwebel,James Scott,Soraya Seedat,Sadaf G. Sepanlou,Berrin Serdar,Edson Serván-Mori,Gavin Shaddick,Saeid Shahraz,Teresa Shamah Levy,Siyi Shangguan,Jun She,Sara Sheikhbahaei,Kenji Shibuya,Hwashin H. Shin,Yukito Shinohara,Rahman Shiri,Kawkab Shishani,Ivy Shiue,Inga Dora Sigfusdottir,Donald H. Silberberg,Edgar P. Simard,Shireen Sindi,Abhishek Singh,Gitanjali M. Singh,Jasvinder A. Singh,Vegard Skirbekk,Karen Sliwa,Michael Soljak,Samir Soneji,Kjetil Søreide,Sergey Soshnikov,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Nicolas J. C. Stapelberg,Vasiliki Stathopoulou,Nadine Steckling,Dan J. Stein,Murray B. Stein,Natalie Stephens,Heidi Stöckl,Kurt Straif,Konstantinos Stroumpoulis,Lela Sturua,Bruno F. Sunguya,Soumya Swaminathan,Mamta Swaroop,Bryan L. Sykes,Karen M. Tabb,Ken Takahashi,Roberto Tchio Talongwa,Nikhil Tandon,David Tanne,Marcel Tanner,Mohammad Tavakkoli,Braden Te Ao,Carolina Maria Teixeira,Martha M Téllez Rojo,Abdullah Sulieman Terkawi,Abdullah Sulieman Terkawi,José Luis Texcalac-Sangrador,Sarah V Thackway,Blake Thomson,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D. Thurston,Taavi Tillmann,Myriam Tobollik,Marcello Tonelli,Fotis Topouzis,Jeffrey A. Towbin,Hideaki Toyoshima,Jefferson Traebert,Bach Xuan Tran,Leonardo Trasande,Matias Trillini,Ulises Trujillo,Zacharie Tsala Dimbuene,Miltiadis K. Tsilimbaris,Emin Murat Tuzcu,Uche S. Uchendu,Kingsley N. Ukwaja,Selen Begüm Uzun,Steven van de Vijver,Rita Van Dingenen,Coen H. Van Gool,Jim van Os,Yuri Y Varakin,Tommi Vasankari,Ana Maria Nogales Vasconcelos,Monica S. Vavilala,Lennert J. Veerman,Gustavo Velasquez-Melendez,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Salvador Villalpando,Francesco Saverio Violante,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Gregory R. Wagner,Gregory R. Wagner,Stephen G Waller,Mitchell T. Wallin,Xia Wan,Haidong Wang,JianLi Wang,Linhong Wang,Wenzhi Wang,Yanping Wang,Tati S. Warouw,Charlotte Watts,Charlotte Watts,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Andrea Werdecker,K. Ryan Wessells,Ronny Westerman,Harvey Whiteford,James D. Wilkinson,Hywel C Williams,Thomas N. Williams,Solomon Meseret Woldeyohannes,Charles D.A. Wolfe,John Q. Wong,Anthony D. Woolf,Jonathan L. Wright,Jonathan L. Wright,Brittany Wurtz,Gelin Xu,Lijing L. Yan,Gonghuan Yang,Yuichiro Yano,Pengpeng Ye,Muluken Azage Yenesew,Gokalp Kadri Yentur,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Zourkaleini Younoussi,Chuanhua Yu,Maysaa El Sayed Zaki,Yong Zhao,Yingfeng Zheng,Maigeng Zhou,Jun Zhu,Shankuan Zhu,Xiaonong Zou,Joseph R. Zunt,Alan D. Lopez,Theo Vos,Christopher J L Murray +736 more
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as discussed by the authors provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.
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TL;DR: The two hypotheses to explain the pathogenesis of atherosclerosis, the "incrustation" hypothesis and the "lipid" hypothesis, are now known.
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Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
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TL;DR: The Coronary Drug Project was conducted to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction, and niacin treatment showed modest benefit in decreasing definite nonfatal recurrent myocardia but did not decrease total mortality.
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By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease
TL;DR: The results from the cohort studies, international comparisons, and clinical trials are remarkably consistent and estimate that a long term reduction in serum cholesterol concentration of 0.6 mmol/l (10%), which can be achieved by moderate dietary change,owers the risk of ischaemic heart disease by 50%" at age 40, falling to 20% at age 70.
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