Journal ArticleDOI
Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion.
Julia A. Haller,Francesco Bandello,Rubens Belfort,Mark S. Blumenkranz,Mark C Gillies,Jeffrey S. Heier,Anat Loewenstein,Young-Hee Yoon,Marie-Louise Jacques,Jenny Jiao,Xiao-yan Li,Scott M. Whitcup +11 more
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TLDR
In this paper, the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc., Irvine, CA) compared with sham in eyes with vision loss due to macular edema (ME) associated with BRVO or central retinal vein occlusion (CRVO).About:
This article is published in Ophthalmology.The article was published on 2010-06-01. It has received 955 citations till now. The article focuses on the topics: Macular edema & Dexamethasone Intravitreal Implant.read more
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TL;DR: This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale, and what might be coming next.
Journal ArticleDOI
Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema.
David S. Boyer,Young Hee Yoon,Rubens Belfort,Francesco Bandello,Raj K. Maturi,Albert J. Augustin,Xiao-yan Li,Harry Cui,Yehia Hashad,Scott M. Whitcup +9 more
TL;DR: The DEX implant 0.7 mg and 0.35 mg met the primary efficacy endpoint for improvement in BCVA, and the safety profile was acceptable and consistent with previous reports.
Journal ArticleDOI
Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal Vein Occlusion: Twelve-Month Study Results
Julia A. Haller,Francesco Bandello,Rubens Belfort,Mark S. Blumenkranz,Mark C Gillies,Jeffrey S. Heier,Anat Loewenstein,Young Hee Yoon,Jenny Jiao,Xiao-yan Li,Scott M. Whitcup +10 more
TL;DR: Among patients with macular edema owing to BRVO or CRVO, single and repeated treatment with DEX implant had a favorable safety profile over 12 months.
Journal ArticleDOI
Dexamethasone Intravitreal Implant for Noninfectious Intermediate or Posterior Uveitis
Careen Y. Lowder,Rubens Belfort,Susan Lightman,C. Stephen Foster,Michael R. Robinson,Rhett M. Schiffman,Xiao-yan Li,Harry Cui,Scott M. Whitcup +8 more
TL;DR: In patients with noninfectious intermediate or posterior uveitis, a single DEX implant significantly improved intraocular inflammation and visual acuity persisting for 6 months.
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TL;DR: This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale, and what might be coming next.
Journal ArticleDOI
A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone With Observation to Treat Vision Loss Associated With Macular Edema Secondary to Central Retinal Vein Occlusion: The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study Report 5
Michael S. Ip,Ingrid U. Scott,Paul C. VanVeldhuisen,Neal Oden,Barbara A Blodi,Marian R. Fisher,Lawrence J. Singerman,Michael J. Tolentino,Clement K. Chan,Victor H. Gonzalez +9 more
TL;DR: Intravitreal triamcinolone is superior to observation for treating vision loss associated with macular edema secondary to CRVO in patients who have characteristics similar to those in the SCORE-CRVO trial.
Journal ArticleDOI
Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.
David A. Antonetti,Alistair J. Barber,Sonny Khin,Erich Lieth,John M. Tarbell,Thomas W. Gardner +5 more
TL;DR: These data show that diabetes selectively reduces retinal occludin protein expression and increases BRB permeability, and suggest that the elevated VEGF in the vitreous of patients with diabetic retinopathy increases vascular permeability by downregulating occlUDin content.
Journal Article
The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study.
TL;DR: The data suggest a strong association between retinal branch vein occlusion and retinal arteriolar changes, and data from larger populations are needed to further assess associations between risk factors and the incidence of retinal vein Occlusion.