Rapid diagnostic tests for identifying avian influenza A(H7N9) virus in clinical samples.
Yu Chen,Dayan Wang,Shufa Zheng,Yuelong Shu,Wenxiang Chen,Dawei Cui,Jinming Li,Hongjie Yu,Yu Wang,Lanjuan Li,Hong Shang +10 more
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TLDR
To determine sensitivity of rapid diagnostic tests for detecting influenza A(H7N9) virus, this work compared rapid tests with PCR results and tested different types of clinical samples.Abstract:
To determine sensitivity of rapid diagnostic tests for detecting influenza A(H7N9) virus, we compared rapid tests with PCR results and tested different types of clinical samples. Usefulness of seasonal influenza rapid tests for A(H7N9) virus infections is limited because of their low sensitivity for detecting virus in upper respiratory tract specimens.read more
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Recent developments in the diagnosis of avian influenza.
TL;DR: The diagnosis of influenza A virus infections in poultry or wild birds is difficult due to variations in the pathogenicity of the viruses in different avian hosts and the antigenic and genetic diversity of the virus, particularly the recent H5 highly pathogenic avian influenza viruses.
Journal ArticleDOI
A sandwich ELISA for the detection of neuraminidase of avian influenza A(H7N9) virus.
Yueyang Yu,Xi Zhang,Baihui Zhao,Ying Sun,Xiaoguang Zhang,Tian Bai,Jian Lu,Zi Li,Liqi Liu,Dayan Wang,Yuelong Shu,Jianfang Zhou,Kun Qin +12 more
TL;DR: The ELISA using anti-N9 mAbs provided a valuable approach to detect H7N9 virus and quantify the N9 protein.
Journal ArticleDOI
Rapid Detection of Avian Influenza A Virus (H7N9) by Lateral Flow Dipstick Recombinase Polymerase Amplification.
TL;DR: A lateral flow dipstick recombinase polymerase amplification (LFD-RPA) assay for rapid detection of both hemagglutinin and neuraminidase gene of H7N9 shows 100% analytical specificity and sufficient analytical sensitivity results agreed the real time RT-PCR assay.
Journal ArticleDOI
Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review.
Wen-Hung Wang,Erazo Em,Ishcol Mrc,Chun-Hsuan Lin,Wanchai Assavalapsakul,Arunee Thitithanyanont,Sheng-Fan Wang +6 more
TL;DR: A systemic review regarding virus-induced pathogenesis, vaccine development, and diagnosis of H7N9 AIV infection in humans finds mechanisms via which the virus induces severe syndromes remain unclear.
Journal ArticleDOI
A “Turn-on” fluorescent bioprobe with aggregation-induced emission characteristics for detection of influenza virus-specific hemagglutinin protein
Xiaoling Pan,Pai Liu,Xinghui Wu,Yahui Zhang,Zhengxu Cai,Jianbing Shi,Junge Zhi,Zi Li,Dayan Wang,Bin Tong,Yuping Dong +10 more
TL;DR: In this paper, four hexaphenyl-butadiene pyridine salt derivatives (HPB-Xs) with aggregation-induced emission (AIE) characteristics were designed and synthesized.
References
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Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Clinical findings in 111 cases of influenza A (H7N9) virus infection
Hainv Gao,Hongzhou Lu,Bin Cao,Bin Du,Hong Shang,Jianhe Gan,Shuihua Lu,Yida Yang,Qiang Fang,Yinzhong Shen,Xiuming Xi,Qin Gu,Xian-Mei Zhou,Hong-Ping Qu,Zheng Yan,Fang-Ming Li,Wei Zhao,Zhancheng Gao,Guang-Fa Wang,Lingxiang Ruan,Weihong Wang,Jun Ye,Hui-Fang Cao,Xingwang Li,Wenhong Zhang,Xu-Chen Fang,Jian He,Weifeng Liang,Juan Xie,Mei Zeng,Xianzheng Wu,Jun Li,Qi Xia,Zhao-Chen Jin,Qi Chen,Chao Tang,Zhiyong Zhang,Bao-Min Hou,Zhi-Xian Feng,Jifang Sheng,Nanshan Zhong,Lanjuan Li +41 more
TL;DR: The presence of a coexisting medical condition was the only independent risk factor for the acute respiratory distress syndrome (ARDS) during the evaluation period, and the novel H7N9 virus caused severe illness, including pneumonia and ARDS, with high rates of ICU admission and death.
Journal ArticleDOI
Biological features of novel avian influenza A (H7N9) virus
Jiangfang Zhou,Dayan Wang,Rongbao Gao,Baihui Zhao,Jingdong Song,Xian Qi,Yanjun Zhang,Yonglin Shi,Lei Yang,Wenfei Zhu,Tian Bai,Kun Qin,Yu Lan,Shumei Zou,Junfeng Guo,Jie Dong,Libo Dong,Ye Zhang,Hejiang Wei,Xiaodan Li,Jian Lu,Liqi Liu,Xiang Zhao,Xiyan Li,Weijuan Huang,Le-ying Wen,Hong Bo,Li Xin,Y. Chen,Cuilin Xu,Yuquan Pei,Yue Yang,Xiaodong Zhang,Shiwen Wang,Zijian Feng,Jun Han,Weizhong Yang,George F. Gao,Guizhen Wu,Dexin Li,Yu Wang,Yuelong Shu +41 more
TL;DR: It is shown that the emerging H7N9 avian influenza virus poses a potentially high risk to humans, and current seasonal vaccination could not provide protection.
Journal ArticleDOI
Biomarker correlates of survival in pediatric patients with Ebola virus disease.
Anita K. McElroy,Bobbie R. Erickson,Timothy D. Flietstra,Pierre E. Rollin,Stuart T. Nichol,Jonathan S. Towner,Christina F. Spiropoulou +6 more
TL;DR: Children who had certain endothelial and immune function markers were more likely to survive infection and be diagnosed with infection later in life.
Journal ArticleDOI
Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses.
Yuko Sakai-Tagawa,Makoto Ozawa,Makoto Ozawa,Daisuke Tamura,Mai thi Quynh Le,Chairul A. Nidom,Norio Sugaya,Yoshihiro Kawaoka +7 more
TL;DR: The results indicate that the detection sensitivity to swine origin H1N1 viruses varies widely among IRDTs, with some tests lacking sufficient sensitivity to detect the early stages of infection when the virus load is low.