Rapid direct injection LC-MS/MS method for analysis of prioritized indicator compounds in wastewater effluent
Tarun Anumol,Shimin Wu,Mauricius Marques dos Santos,Kevin D. Daniels,Shane A. Snyder +4 more
- Vol. 1, Iss: 5, pp 632-643
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TLDR
In this paper, the authors used a detailed literature review and scoring system to establish a list of twenty priority indicator trace organic compounds (TOrCs) in US wastewaters.Abstract:
Trace organic compounds (TOrCs) have been detected in drinking water sources for several years, raising concerns due to their potential risks to public health. The main contributor of TOrCs to drinking water is through wastewater discharges. However, there are several hundred TOrCs currently known with numerous new organic chemicals being released daily, making it unfeasible to monitor each one in water. This study used a detailed literature review and scoring system to establish a list of twenty priority indicator TOrCs in US wastewaters. Next, a rapid direct injection LC-MS/MS method for analysis of these compounds was developed without the need for an extraction step and only 80 μL sample volume while providing method reporting limits of 3–39 ng L−1 for all but one TOrC (sucralose: 302 ng L−1). The elimination of an extraction step reduced matrix effects considerably making the method suitable for wastewater analysis. Method validation including matrix spike recoveries, linearity of calibration curve and inter- and intra-day variability was successfully performed. Finally, the twenty indicator TOrCs were evaluated in four different wastewater treatment plant (WWTP) effluents through four sample campaigns spread across a year. The occurrence data indicated that all indicator TOrCs were detected in at least three out of the four WWTP effluents. Sucralose, iohexol, TCPP, acesulfame and gemfibrozil were detected in all samples at the four WWTPs indicating they could be used as indicators of wastewater influence in receiving waters. DEET, caffeine, triclosan, iopromide and others are effective indicators at showing seasonal variations, treatment process efficacy, and consumption patterns. Overall, the impact of this study will help develop more effective monitoring programs for TOrCs in water reuse schemes.read more
Citations
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Temporal and spatial variation in pharmaceutical concentrations in an urban river system
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Fast determination of pesticides and other contaminants of emerging concern in treated wastewater using direct injection coupled to highly sensitive ultra-high performance liquid chromatography-tandem mass spectrometry
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Occurrence and fate of emerging trace organic chemicals in wastewater plants in Chennai, India.
TL;DR: The effluent composition of the 22 TOrCs were similar within the three WWTPs but quite different to those seen in the US, indicating the importance of region-specific monitoring.
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References
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Rapid analysis of trace organic compounds in water by automated online solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry.
Tarun Anumol,Shane A. Snyder +1 more
TL;DR: A fully automated online solid-phase extraction with directly coupled liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for analysis of 34 trace organic compounds in diverse water matrices has been developed and offers several advantages over traditional offline SPE methods including low sample volume, decreased solvent use, higher throughput, and increased reproducibility.
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Role of primary substrate composition and concentration on attenuation of trace organic chemicals in managed aquifer recharge systems
TL;DR: The composition and concentration of thePrimary substrate had an effect on attenuation of moderately degradable TOrCs, such as atenolol, gemfibrozil and diclofenac, with the primary substrate composition seeming to have a larger impact on TOrC attenuation than its concentration.
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Mechanism considerations for photocatalytic oxidation, ozonation and photocatalytic ozonation of some pharmaceutical compounds in water.
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