Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
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...Indeed, given the much larger space occupied by nonsynaptic regions, nonsynaptic AMPARs appear to outnumber synaptic AMPARs by quite a large margin (Shi et al. 1999)....
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...This restriction from synapses is in contrast with what is found in dissociated cultured neurons in which expression of recombinant GluR1 concentrates at synapses (Lissin et al. 1998, Shi et al. 1999)....
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...Optical Detection of Recombinant AMPA Receptor Trafficking During LTP To monitor AMPAR trafficking in living tissue, one study generated and acutely expressed GFP-tagged GluR1 receptors in organotypic hippocampal slices (Shi et al. 1999)....
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...After NMDA receptor activation, AMPA receptors can move into spine...
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