Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
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...Second, our maps show which mutations can be introduced into the RBD without disrupting key biochemical phenotypes, thereby opening the door to resurfacing immunogens to focus antibodies on specific epitopes (Duan et al., 2018; Eggink et al., 2014; Jardine et al., 2016; Kulp et al., 2017; Weidenbacher and Kim, 2019; Wu et al., 2010)....
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...However, there are other surface positions where introduction of NxS/T glycosylation motifs is tolerated or even beneficial for RBD expression (Figures S5G–S5I); adding glycans at some of these sites could be useful in resurfacing RBDs as antibody probes (Wu et al., 2010; Zhou et al., 2020c) or epitope-focused immunogens (Duan et al....
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