Rauwolfia serpentina Benth
About: This article is published in Archiv Der Pharmazie.The article was published on 1932-01-01. It has received 34 citations till now.
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TL;DR: The sedative principle of Rauwolfia serpentina Benth has been isolated in pure crystalline form and its chemistry and pharmacology has been studied as discussed by the authors, and its properties and properties have been investigated.
Abstract: The sedative principle ofRauwolfia serpentina Benth. has been isolated in pure crystalline form and its chemistry and pharmacology has been studied.
199 citations
173 citations
TL;DR: This review will summarize recent applications of asymmetric organocatalysis in the enantioselective synthesis of indole alkaloids.
Abstract: Indole and its structural analogues have been frequently found in numerous alkaloids, pharmaceutical products and related materials. The enantioselective construction of these structures allows efficient total synthesis of optically pure indole alkaloids, and hence has received worldwide interest. In the past decade, asymmetric organocatalysis has been recognized as one of the most powerful strategies to create chiral molecules with high levels of stereoselectivity. In particular, organocatalytic asymmetric cascade reactions often occur with multiple bond-breaking and forming events simultaneously or sequentially, leading to the appearance of various straightforward approaches to access core structures for asymmetric total synthesis. This review will summarize recent applications of asymmetric organocatalysis in the enantioselective synthesis of indole alkaloids.
92 citations
TL;DR: A new concept of the ionization of highly acidic compounds as the protonated complexes with basic peptides, which allows the accurate determination of the molecular weights of the former, a highly sensitive method for the sequencing of heparin fragments and related sulfated glycosaminoglycans was developed more recently.
55 citations
Cites background from "Rauwolfia serpentina Benth"
...An early success was an alkaloid isolated in 1932 from the root of Rauwolfia serpentina and named reserpine [1]....
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TL;DR: The whole subject of Rauwolfia serpentina therapy in hypertension has been reviewed up to the present time, including discussions on the history of the plant, its various species and types, nomenclature, geographic distribution, chemistry, pharmacologic actions and clinical studies, reported from all over the world.
Abstract: The root of the Rauwolfia serpentina Benth (N. O. Apocyanaciae) has been in use in India for hundreds of years for a host of unrelated ailments. Since 1949, after the English publication of a clinical report by the author on Rauwolfia serpentina therapy in fifty cases of essential hypertension, the plant has gained universal acclamation as a useful therapeutic weapon in high blood pressure states. The whole subject of Rauwolfia serpentina therapy in hypertension has been reviewed up to the present time, including discussions on the history of the plant, its various species and types, nomenclature, geographic distribution, chemistry, pharmacologic actions and clinical studies, reported on the subject from all over the world.
50 citations