Re-emergence of fatal human influenza A subtype H5N1 disease
Jsm Peiris,W C Yu,C W Leung,CY Cheung,Wai F. Ng,John M. Nicholls,Ting Kin Ng,KH Chan,Sik To Lai,W L Lim,Kwok-Yung Yuen,Yi Guan +11 more
Reads0
Chats0
TLDR
Findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease and development of vaccines against influenza A (H5N 1) virus should be made a priority.About:
This article is published in The Lancet.The article was published on 2004-02-21 and is currently open access. It has received 809 citations till now. The article focuses on the topics: Orthomyxoviridae & Influenza A virus subtype H5N1.read more
Citations
More filters
Journal ArticleDOI
Correction: Corrigendum: The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
Jing Guo,Fengming Huang,Jun Liu,Yu Chen,Wei Wang,Bin Cao,Zhen Zou,Song Liu,Jingcao Pan,Changjun Bao,Mei Zeng,Haixia Xiao,Hainv Gao,Shigui Yang,Yan Zhao,Qiang Liu,Huandi Zhou,Jingdong Zhu,Xiaoli Liu,Weifeng Liang,Yida Yang,Shufa Zheng,Jiezuan Yang,Hongyan Diao,Kunkai Su,Li Shao,Hongcui Cao,Ying Wu,Min Zhao,Shuguang Tan,Hui Li,Xiaoqing Xu,Chunmei Wang,Jianmin Zhang,Li Wang,Jianwei Wang,Jun Xu,Dangsheng Li,Nanshan Zhong,Xuetao Cao,George F. Gao,Lanjuan Li,Chengyu Jiang +42 more
TL;DR: This Article contains typographical errors in Table 2 where ‘Week 2 (N = 32)’ was incorrectly given as ‘week (n’=2’.
Journal ArticleDOI
The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
Journal ArticleDOI
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
Menno D. de Jong,Cameron P. Simmons,Tran Tan Thanh,Vo Minh Hien,Gavin J. D. Smith,Tran Nguyen Bich Chau,Dang Minh Hoang,Nguyen Van Vinh Chau,Truong Huu Khanh,Vo Cong Dong,Phan Tu Qui,Bach Van Cam,Do Quang Ha,Yi Guan,J. S. Malik Peiris,Nguyen Tran Chinh,Tran Tinh Hien,Jeremy Farrar +17 more
TL;DR: The observations indicate that high viral load, and the resulting intense inflammatory responses, are central to influenza H5N1 pathogenesis and the focus of clinical management should be on preventing this intense cytokine response, by early diagnosis and effective antiviral treatment.
Journal ArticleDOI
1918 Influenza: the Mother of All Pandemics
TL;DR: In this paper, the authors discuss the public health implications of the Spanish influenza pandemic of 1918-1919, which caused ≈50 million deaths worldwide and remains an ominous warning to public health.
Journal ArticleDOI
Into the Eye of the Cytokine Storm
Jennifer R. Tisoncik,Marcus J. Korth,Cameron P. Simmons,Jeremy Farrar,Thomas R. Martin,Michael G. Katze +5 more
TL;DR: How high-throughput genomic methods are revealing the importance of the kinetics of cytokine gene expression and the remarkable degree of redundancy and overlap in cytokine signaling is highlighted.
References
More filters
Journal ArticleDOI
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
E.C.J. Claas,Albert D. M. E. Osterhaus,Ruud van Beek,Jan C. de Jong,Guus F. Rimmelzwaan,Dennis A. Senne,Scott Krauss,Kennedy F. Shortridge,Robert G. Webster +8 more
TL;DR: The results suggest transmission of the virus from infected chickens to the child without another intermediate mammalian host acting as a "mixing vessel" illustrates the importance of intensive global influenza surveillance.
Journal ArticleDOI
Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.
Kwok-Yung Yuen,Paul K.S. Chan,Malik Peiris,D. N. C. Tsang,Tak-Lun Que,Kennedy F. Shortridge,P. T. Cheung,W. K. To,E. T. F. Ho,R. Sung,A. F. B. Cheng +10 more
TL;DR: Avian Influenza A H5N1 virus causes human influenza-like illness with a high rate of complications in adults admitted to hospital, and rapid H5-subtype-specific laboratory diagnosis can be made by RT-PCR applied directly to clinical specimens.
Journal ArticleDOI
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
Chung Y. Cheung,Leo L.M. Poon,A S Lau,Winsie Luk,Yu-Lung Lau,Kennedy F. Shortridge,Stephen B. Gordon,Yi Guan,Jsm Peiris +8 more
TL;DR: The H5N1/97 viruses induced much higher gene transcription of proinflammatory cytokines than did H3N2 or H1N1 viruses, particularly TNF alpha and interferon beta, which may contribute to the unusual severity of human H 5N1 disease.
Journal ArticleDOI
Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands
Marion Koopmans,Berry Wilbrink,Marina Conyn,G Natrop,Hans van der Nat,Harry Vennema,Adam Meijer,Jim E. van Steenbergen,Ron A. M. Fouchier,Albert D. M. E. Osterhaus,A Bosman +10 more
TL;DR: An unexpectedly high number of transmissions of avian influenza A virus subtype H7N7 to people directly involved in handling infected poultry, and evidence for person-to-person transmission are noted.
Journal ArticleDOI
Pathology of fatal human infection associated with avian influenza A H5N1 virus.
Ka Fai To,Paul K.S. Chan,Kui-Fat Chan,Wai-Ki Lee,Woon-Yee Lam,Kit-Fai Wong,Nelson L.S. Tang,Dominic N.C. Tsang,Rita Y T Sung,T. A. Buckley,John S. Tam,Augustine F. B. Cheng +11 more
TL;DR: It is postulated that in fatal human infections with this avian subtype, initial virus replication in the respiratory tract triggers hypercytokinemia complicated by the reactive hemophagocytic syndrome.
Related Papers (5)
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.
Kanta Subbarao,Alexander Klimov,Alexander Klimov,Alexander Klimov,Jacqueline M. Katz,Jacqueline M. Katz,Jacqueline M. Katz,Helen L. Regnery,Helen L. Regnery,Helen L. Regnery,Wilina Lim,Wilina Lim,Wilina Lim,Henrietta Hall,Henrietta Hall,Henrietta Hall,Michael L. Perdue,Michael L. Perdue,Michael L. Perdue,David E. Swayne,David E. Swayne,David E. Swayne,Catherine A. Bender,Catherine A. Bender,Catherine A. Bender,Jing Huang,Jing Huang,Jing Huang,Mark L. Hemphill,Mark L. Hemphill,Mark L. Hemphill,Thomas Rowe,Thomas Rowe,Thomas Rowe,Michael W. Shaw,Michael W. Shaw,Michael W. Shaw,Xiyan Xu,Xiyan Xu,Xiyan Xu,Keiji Fukuda,Keiji Fukuda,Keiji Fukuda,Nancy Cox,Nancy Cox,Nancy Cox +45 more