Recent advances and therapeutic journey of coumarins: current status and perspectives
Citations
349 citations
Cites background from "Recent advances and therapeutic jou..."
..., the coumarin scaffold characterizes a large variety of biologically active natural products, pharmaceuticals, agrochemicals, and polymeric [2] and optoelectronic [3] materials....
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...Industrial interest on coumarins led to the development of cosmetics, agrochemicals, polymeric [2], and optoelectronic materials [3]....
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125 citations
Cites background from "Recent advances and therapeutic jou..."
...The former one faces phase II conjugation reaction resulting in the glucuronide derivative, whereas 3-hydroxycoumarin can be further metabolized by ring splitting to form two products, o-hydroxyphenyllactic acid and ohydroxyphenylacetic acid (Figure 2) [4,21]....
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...Since the expression of CYP2A6 varies between individuals, due to genetic and e viro me tal factors, an inter-individual v riation in the metabolism f coum rin drugs is pos ible [4]....
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...The history of these natural products began 200 years ago—the name of the class derived from the plant Coumarouna odorata (Dipteryx odorata) from which the simplest member of this family, coumarin itself (Figure 1), was isolated by Vogel in 1820 [3,4]....
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...Since the expression of CYP2A6 varies between individuals, due to genetic and environmental factors, an inter-individual variation in the metabolism of coumarin drugs is possible [4]....
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...The former one faces phase II conjugation reaction resulting in the glucuronide derivative, whereas 3-hydroxycoumarin can be further metabolized by ring splitting to form two products, o-hydroxyphenyllactic acid and o-hydroxyphenylacetic acid (Figure 2) [4,21]....
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98 citations
Cites background from "Recent advances and therapeutic jou..."
...Coumarins have been proven to have multiple substitution sites, and different substitutions in these sites significantly affect the biological activity of coumarins [16,21,22]....
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...Which include antibacterial, antifungal, anticoagulant, antioxidant, anticancer, and anti-inflammatory properties [16,17]....
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97 citations
References
2,678 citations
"Recent advances and therapeutic jou..." refers background in this paper
...As compare with alkaloids synthesized through shikimic acid pathways, many compounds in which the nucleus is alkylated by one or more isoprenoid units (Barton and Ollis, 1979)....
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1,633 citations
"Recent advances and therapeutic jou..." refers background in this paper
...Induction of apoptosis produces potent inhibitory effect of compound 49 through activating Bax, p53 and p21 expression in a dose-dependent manner (Kim et al., 2010)....
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...…gastric cancer cells with IC50 value of 42.70 lM and inhibited the proliferation of the AGS cells at rate of about 54 % at 100 lM. Induction of apoptosis produces potent inhibitory effect of compound 49 through activating Bax, p53 and p21 expression in a dose-dependent manner (Kim et al., 2010)....
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1,066 citations
"Recent advances and therapeutic jou..." refers methods in this paper
...4-Phenylcoumarins 22 and 23 were isolated from Marila pluricostata (Carpenter et al., 2000) and were found to suppress HIV-1 replication in Jurkat T cells....
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874 citations
"Recent advances and therapeutic jou..." refers background in this paper
...5-LOX represents a dioxygenase that possesses two distinct enzymatic activities leading to the formation of LTA4, which is converted to 5-hydroxyeicosatetraenoic acid (5-HETE) or five lipoxygenase activating protein (FLAP) (Hoult and Paya, 1996a, b)....
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...Coumarins (1,2-benzopyrone) have fused benzene and a-pyrone rings which are present in specific amounts in plants and more than 1300 coumarins were identified from natural sources (Hoult and Paya, 1996a, b)....
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821 citations
"Recent advances and therapeutic jou..." refers background or methods in this paper
...This system was used for the preparation of esterase-sensitive prodrugs of amine-containing compounds or peptides (Wang et al., 1996a, b; Borges et al., 2005a, b)....
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...3; Borges et al., 2005a, b)....
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...New fluorescent probes of novel coumarins are developed by fluorescent spectroscopic studies, which are applied either in water or in micelles (Borges et al., 2005a, b; Baloglu et al., 2001)....
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