Recent advances in biological production of 3-hydroxypropionic acid
TL;DR: The constraints of microbial 3-HP production and possible solutions are described, and the future prospects of biological 3-hydroxypropionic acid production are discussed.
About: This article is published in Biotechnology Advances.The article was published on 2013-11-01. It has received 249 citations till now. The article focuses on the topics: Glycerol dehydratase.
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TL;DR: Recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass to IPCs (i.e., ethanol, 3-hydroxypropionic acid, isoprene, succinic and levulinic acids, furfural, and 5-hydroxymethylfurfural) are overviewed.
Abstract: The replacement of fossil resources that currently provide more than 90% of our energy needs and feedstocks of the chemical industry in combination with reduced emission of carbon dioxide is one of the most pressing challenges of mankind. Biomass as a globally available resource has been proposed as an alternative feedstock for production of basic building blocks, which could partially or even fully replace the currently utilized fossil-based ones in well-established chemical processes. The destruction of lignocellulosic feed followed by oxygen removal from its cellulose and hemicellulose content by catalytic processes results in the formation of initial platform chemicals (IPCs). However, their sustainable production strongly depends on the availability of resources, their efficient or even industrially viable conversion processes, and replenishment time of feedstocks. Herein, we overview recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass ...
784 citations
TL;DR: It is evident that fermentative production of chemicals and biopolymers via refining of waste and by-product streams is a highly important research area with significant prospects for industrial applications.
Abstract: The transition from a fossil fuel-based economy to a bio-based economy necessitates the exploitation of synergies, scientific innovations and breakthroughs, and step changes in the infrastructure of chemical industry. Sustainable production of chemicals and biopolymers should be dependent entirely on renewable carbon. White biotechnology could provide the necessary tools for the evolution of microbial bioconversion into a key unit operation in future biorefineries. Waste and by-product streams from existing industrial sectors (e.g., food industry, pulp and paper industry, biodiesel and bioethanol production) could be used as renewable resources for both biorefinery development and production of nutrient-complete fermentation feedstocks. This review focuses on the potential of utilizing waste and by-product streams from current industrial activities for the production of chemicals and biopolymers via microbial bioconversion. The first part of this review presents the current status and prospects on fermentative production of important platform chemicals (i.e., selected C2-C6 metabolic products and single cell oil) and biopolymers (i.e., polyhydroxyalkanoates and bacterial cellulose). In the second part, the qualitative and quantitative characteristics of waste and by-product streams from existing industrial sectors are presented. In the third part, the techno-economic aspects of bioconversion processes are critically reviewed. Four case studies showing the potential of case-specific waste and by-product streams for the production of succinic acid and polyhydroxyalkanoates are presented. It is evident that fermentative production of chemicals and biopolymers via refining of waste and by-product streams is a highly important research area with significant prospects for industrial applications.
431 citations
TL;DR: Current technological advances on industrial strain development for the production of platform chemicals using micro-organisms will be covered in detail with case studies on succinic acid and 3-hydroxypropionic acid as examples.
415 citations
Cites background or methods from "Recent advances in biological produ..."
...The theoretical maximum yield of 3-HP from glucose is almost 2 mol/mol (Kumar et al., 2013)....
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...After the publication of the report, many promising pathways were suggested and experiments were performed to produce 3-HP via biological routes (Kumar et al., 2013; Valdehuesa et al., 2013)....
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...7(C)), have been reported for the production of 3-HP from glycerol (Kumar et al., 2013; Valdehuesa et al., 2013)....
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...Two pathways, the CoA-dependent and CoA-independent pathways, have been reported for 3-HP production using glycerol as carbon source (Kumar et al., 2013)....
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...denitrificans is the only known oxygen-insensitive one (Kumar et al., 2013)....
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TL;DR: In this article, the authors classified the biomass into four general types based on their origin: energy crops, agricultural residues and waste, forestry waste and residues and industrial and municipal wastes, and provided an overview of different types of biorefinery, broad challenges and availability of biomass.
Abstract: Sustainable production of energy, fuels, organic chemicals and polymers from biomass in an integrated biorefinery is extremely important to reduce enslavement on limited fossil fuels. In the present article, the biomass was classified into four general types based on their origin: energy crops, agricultural residues and waste, forestry waste and residues and industrial and municipal wastes. The article further elucidates the chemistry of various types of biomass used in the biorefinery. The biorefinery was classified into three broad categories based on the chemistry of biomass: triglyceride, sugar and starchy and lignocellulosic. The article further presents a comprehensive outlines of opportunities and recent trends of each type of biorefinery. A brief overview of original and revised list of platform chemicals, their sources from biomass and derivative potentials were also articulated. The article also provides comparisons of different types of biorefinery, broad challenges and availability of biomass. Furthermore, the article provides an overview of hydrocarbon biorefinery for production of hydrocarbon fuels and building block chemicals from biomass.
340 citations
TL;DR: This review article provides an overview of the techniques developed for the valorization of biomass in the production of platform chemicals within a biorefinery and the status for commercialization.
Abstract: Until recently, most of energy and industrially produced chemicals were derived from fossil fuel-based resources. This along with the continued depletion of finite fossil resources and their attributed adverse environmental impacts, alternatively sourced and more sustainable resources are being pursued as feedstock replacements. Thus, biomass has been identified as an alternate renewable and more sustainable resource as a means to reduce this sector's dependence on fossil fuel-based resources and to alleviate their environmental impacts. As such, lignocellulosic biomass has been further identified and demonstrated as an abundant renewable resource for the production of biofuels, platform chemicals, and their respective value-added products. This review article provides an overview of the techniques developed for the valorization of biomass in the production of platform chemicals within a biorefinery, and the status for commercialization.
282 citations
References
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01 Aug 2004
TL;DR: In this paper, the authors identified twelve building block chemicals that can be produced from sugar via biological or chemical conversions, and the twelve building blocks can be subsequently converted to a number of high-value bio-based chemicals or materials.
Abstract: This report identifies twelve building block chemicals that can be produced from sugars via biological or chemical conversions. The twelve building blocks can be subsequently converted to a number of high-value bio-based chemicals or materials. Building block chemicals, as considered for this analysis, are molecules with multiple functional groups that possess the potential to be transformed into new families of useful molecules. The twelve sugar-based building blocks are 1,4-diacids (succinic, fumaric and malic), 2,5-furan dicarboxylic acid, 3-hydroxy propionic acid, aspartic acid, glucaric acid, glutamic acid, itaconic acid, levulinic acid, 3-hydroxybutyrolactone, glycerol, sorbitol, and xylitol/arabinitol.
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1,140 citations
TL;DR: iJR904 will help to outline the genotype-phenotype relationship for E. coli K-12, as it can account for genomic, transcriptomic, proteomic and fluxomic data simultaneously, and has improved capabilities over iJE660a.
Abstract: Diverse datasets, including genomic, transcriptomic, proteomic and metabolomic data, are becoming readily available for specific organisms. There is currently a need to integrate these datasets within an in silico modeling framework. Constraint-based models of Escherichia coli K-12 MG1655 have been developed and used to study the bacterium's metabolism and phenotypic behavior. The most comprehensive E. coli model to date (E. coli iJE660a GSM) accounts for 660 genes and includes 627 unique biochemical reactions. An expanded genome-scale metabolic model of E. coli (iJR904 GSM/GPR) has been reconstructed which includes 904 genes and 931 unique biochemical reactions. The reactions in the expanded model are both elementally and charge balanced. Network gap analysis led to putative assignments for 55 open reading frames (ORFs). Gene to protein to reaction associations (GPR) are now directly included in the model. Comparisons between predictions made by iJR904 and iJE660a models show that they are generally similar but differ under certain circumstances. Analysis of genome-scale proton balancing shows how the flux of protons into and out of the medium is important for maximizing cellular growth. E. coli iJR904 has improved capabilities over iJE660a. iJR904 is a more complete and chemically accurate description of E. coli metabolism than iJE660a. Perhaps most importantly, iJR904 can be used for analyzing and integrating the diverse datasets. iJR904 will help to outline the genotype-phenotype relationship for E. coli K-12, as it can account for genomic, transcriptomic, proteomic and fluxomic data simultaneously.
1,102 citations
"Recent advances in biological produ..." refers methods in this paper
...E. coli was used as a model microorganism and anaerobic cultivation with glucose as the sole carbon source was assumed (Reed et al., 2003)....
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TL;DR: Glycerol bioconversion in valuable chemicals, such as 1,3-propanediol, dihydroxyacetone, ethanol, succinate etc. is discussed in this review article.
1,031 citations
"Recent advances in biological produ..." refers background in this paper
...The use of crude glycerol has been explored as a carbon source for microbial fermentation to produce a range of biochemicals and biofuels (da Silva et al., 2009; Dobson et al., 2012)....
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