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Journal ArticleDOI: 10.1016/J.MSEC.2021.112005

Recent Advances in Bioprinting Technologies for Engineering Different Cartilage-based Tissues

04 Mar 2021-Materials Science and Engineering: C (Elsevier BV)-Vol. 123, pp 112005-112005
Abstract: Inadequate self-repair and regenerative efficiency of the cartilage tissues has motivated the researchers to devise advanced and effective strategies to resolve this issue. Introduction of bioprinting to tissue engineering has paved the way for fabricating complex biomimetic engineered constructs. In this context, the current review gears off with the discussion of standard and advanced 3D/4D printing technologies and their implications for the repair of different cartilage tissues, namely, articular, meniscal, nasoseptal, auricular, costal, and tracheal cartilage. The review is then directed towards highlighting the current stem cell opportunities. On a concluding note, associated critical issues and prospects for future developments, particularly in this sphere of personalized medicines have been discussed.

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Journal ArticleDOI: 10.1016/J.MSEC.2021.112013
Abstract: In the sphere of liver tissue engineering (LTE), 3D bioprinting has emerged as an effective technology to mimic the complex in vivo hepatic microenvironment, enabling the development of functional 3D constructs with potential application in the healthcare and diagnostic sector. This review gears off with a note on the liver's microscopic 3D architecture and pathologies linked to liver injury. The write-up is then directed towards unmasking recent advancements and prospects of bioprinting for recapitulating 3D hepatic structure and function. The article further introduces available stem cell opportunities and different strategies for their directed differentiation towards various hepatic stem cell types, including hepatocytes, hepatic sinusoidal endothelial cells, stellate cells, and Kupffer cells. Another thrust of the article is on understanding the dynamic interplay of different hepatic cells with various microenvironmental cues, which is crucial for controlling differentiation, maturation, and maintenance of functional hepatic cell phenotype. On a concluding note, various critical issues and future research direction towards clinical translation of bioprinted hepatic constructs are discussed.

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6 Citations


Journal ArticleDOI: 10.1016/J.APMT.2021.101107
Pooyan Makvandi1, Atefeh Zarepour2, Xuan-Qi Zheng3, Tarun Agarwal4  +12 moreInstitutions (10)
Abstract: Non-spherical metal nanomaterials such as noble metal or transition metal dichalcogenides and MXenes have been employed in different biomedical facets. Because the biological properties of these nanocompounds are governed by their architecture and composition, such factors should be considered prior to their adoption for clinical use. The architecture of metal-based nanomaterials affects cell viability by virtue of the variable geometry of these nanomaterials as well as their physicochemical interactions with mammalian cell membranes. In the present review, the effects of parameters such as interfacial interaction and aspect ratio on cellular uptake of non-spherical metallic nanomaterials will be discussed. The application of these nanomaterials as biosensors, in cancer diagnosis and therapy, tissue engineering and regenerative medicine will also be thoroughly reviewed.

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Topics: Nanomedicine (53%), MXenes (52%), Nanomaterials (51%)

4 Citations


Open accessJournal ArticleDOI: 10.3389/FCELL.2021.661802
Hao Li, Pinxue Li, Zhen Yang, Cangjian Gao  +10 moreInstitutions (3)
Abstract: Knee menisci are structurally complex components that preserve appropriate biomechanics of the knee. Meniscal tissue is susceptible to injury and cannot heal spontaneously from most pathologies, especially considering the limited regenerative capacity of the inner avascular region. Conventional clinical treatments span from conservative therapy to meniscus implantation, all with limitations. There have been advances in meniscal tissue engineering and regenerative medicine in terms of potential combinations of polymeric biomaterials, endogenous cells and stimuli, resulting in innovative strategies. Recently, polymeric scaffolds have provided researchers with a powerful instrument to rationally support the requirements for meniscal tissue regeneration, ranging from an ideal architecture to biocompatibility and bioactivity. However, multiple challenges involving the anisotropic structure, sophisticated regenerative process, and challenging healing environment of the meniscus still create barriers to clinical application. Advances in scaffold manufacturing technology, temporal regulation of molecular signaling and investigation of host immunoresponses to scaffolds in tissue engineering provide alternative strategies, and studies have shed light on this field. Accordingly, this review aims to summarize the current polymers used to fabricate meniscal scaffolds and their applications in vivo and in vitro to evaluate their potential utility in meniscal tissue engineering. Recent progress on combinations of two or more types of polymers is described, with a focus on advanced strategies associated with technologies and immune compatibility and tunability. Finally, we discuss the current challenges and future prospects for regenerating injured meniscal tissues.

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Topics: Regenerative medicine (51%)

3 Citations


Journal ArticleDOI: 10.1039/D1TB01335A
Tarun Agarwal1, Sung Yun Hann2, Irene Chiesa3, Haitao Cui2  +8 moreInstitutions (5)
Abstract: Nature's material systems during evolution have developed the ability to respond and adapt to environmental stimuli through the generation of complex structures capable of varying their functions across direction, distances and time. 3D printing technologies can recapitulate structural motifs present in natural materials, and efforts are currently being made on the technological side to improve printing resolution, shape fidelity, and printing speed. However, an intrinsic limitation of this technology is that printed objects are static and thus inadequate to dynamically reshape when subjected to external stimuli. In recent years, this issue has been addressed with the design and precise deployment of smart materials that can undergo a programmed morphing in response to a stimulus. The term 4D printing was coined to indicate the combined use of additive manufacturing, smart materials, and careful design of appropriate geometries. In this review, we report the recent progress in the design and development of smart materials that are actuated by different stimuli and their exploitation within additive manufacturing to produce biomimetic structures with important repercussions in different but interrelated biomedical areas.

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Topics: Smart material (55%)

1 Citations


Open accessJournal ArticleDOI: 10.1016/J.BEA.2021.100015
Tarun Agarwal1, Sheri-Ann Tan2, Valentina Onesto3, Jia Xian Law4  +6 moreInstitutions (6)
01 Dec 2021-
Abstract: Engineering constructs with adequate bioactive properties that could support effective repair/ regeneration of damaged tissues is still a persisting challenge. An effective and sustainable approach involving a combination of tissue engineering principles and herbal medicines could address this challenge. This particular domain has witnessed tremendous growth over the past decade. In this review, we provide an overview of engineered herbal constructs for tissue engineering applications. We have highlighted various properties of herbal medicines that are relevant to tissue repair and regeneration. Further, a discussion of different biomaterials, fabrication methods, and current progress made with herbal constructs has been provided. On a concluding note, challenges and outlook for further development and clinical translation of these herbal constructs have also been presented.

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1 Citations


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193 results found


Open accessJournal Article
01 Jan 1993-Science

5,981 Citations


Open accessBook
01 Jan 2009-
Abstract: Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing deals with various aspects of joining materials to form parts. Additive Manufacturing (AM) is an automated technique for direct conversion of 3D CAD data into physical objects using a variety of approaches. Manufacturers have been using these technologies in order to reduce development cycle times and get their products to the market quicker, more cost effectively, and with added value due to the incorporation of customizable features. Realizing the potential of AM applications, a large number of processes have been developed allowing the use of various materials ranging from plastics to metals for product development. Authors Ian Gibson, David W. Rosen and Brent Stucker explain these issues, as well as: Providing a comprehensive overview of AM technologies plus descriptions of support technologies like software systems and post-processing approaches Discussing the wide variety of new and emerging applications like micro-scale AM, medical applications, direct write electronics and Direct Digital Manufacturing of end-use components Introducing systematic solutions for process selection and design for AM Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing is the perfect book for researchers, students, practicing engineers, entrepreneurs, and manufacturing industry professionals interested in additive manufacturing.

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3,013 Citations


Journal ArticleDOI: 10.1002/ADMA.200901141
09 Feb 2010-Advanced Materials
Abstract: In this Progress Report we provide an update on recent developments in inkjet printing technology and its applications, which include organic thin-film transistors, light-emitting diodes, solar cells, conductive structures, memory devices, sensors, and biological/pharmaceutical tasks. Various classes of materials and device types are in turn examined and an opinion is offered about the nature of the progress that has been achieved.

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Topics: Printed electronics (62%)

1,737 Citations


Open accessJournal ArticleDOI: 10.1038/S41467-019-12176-8
Abstract: Policies aiming to preserve vegetated coastal ecosystems (VCE; tidal marshes, mangroves and seagrasses) to mitigate greenhouse gas emissions require national assessments of blue carbon resources. Here, we present organic carbon (C) storage in VCE across Australian climate regions and estimate potential annual CO2 emission benefits of VCE conservation and restoration. Australia contributes 5–11% of the C stored in VCE globally (70–185 Tg C in aboveground biomass, and 1,055–1,540 Tg C in the upper 1 m of soils). Potential CO2 emissions from current VCE losses are estimated at 2.1–3.1 Tg CO2-e yr-1, increasing annual CO2 emissions from land use change in Australia by 12–21%. This assessment, the most comprehensive for any nation to-date, demonstrates the potential of conservation and restoration of VCE to underpin national policy development for reducing greenhouse gas emissions. Policies aiming to preserve vegetated coastal ecosystems (VCE) to mitigate greenhouse gas emissions require national assessments of blue carbon resources. Here the authors assessed organic carbon storage in VCE across Australian and the potential annual CO2 emission benefits of VCE conservation and find that Australia contributes substantially the carbon stored in VCE globally.

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Topics: Greenhouse gas (55%), Climate change mitigation (55%), Blue carbon (53%) ... read more

1,404 Citations


Open accessJournal ArticleDOI: 10.1177/1941738109350438
Abstract: Articular cartilage is the highly specialized connective tissue of diarthrodial joints. Its principal function is to provide a smooth, lubricated surface for articulation and to facilitate the transmission of loads with a low frictional coefficient (Figure 1). Articular cartilage is devoid of blood vessels, lymphatics, and nerves and is subject to a harsh biomechanical environment. Most important, articular cartilage has a limited capacity for intrinsic healing and repair. In this regard, the preservation and health of articular cartilage are paramount to joint health. Figure 1. Gross photograph of healthy articular cartilage in an adult human knee. Injury to articular cartilage is recognized as a cause of significant musculoskeletal morbidity. The unique and complex structure of articular cartilage makes treatment and repair or restoration of the defects challenging for the patient, the surgeon, and the physical therapist. The preservation of articular cartilage is highly dependent on maintaining its organized architecture.

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1,333 Citations


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