Recent Advances in Handedness Genetics
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TLDR
The latest findings from molecular genetic studies are reviewed as well as the implications of using different ways of assessing handedness, which demonstrate that handedness is a highly polygenic trait.Abstract:
Around the world, about 10% people prefer using their left-hand. What leads to this fixed proportion across populations and what determines left versus right preference at an individual level is far from being established. Genetic studies are a tool to answer these questions. Analysis in twins and family show that about 25% of handedness variance is due to genetics. In spite of very large cohorts, only a small fraction of this genetic component can be pinpoint to specific genes. Some of the genetic associations identified so far provide evidence for shared biology contributing to both handedness and cerebral asymmetries. In addition, they demonstrate that handedness is a highly polygenic trait. Typically, handedness is measured as the preferred hand for writing. This is a very convenient measure, especially to reach large sample sizes, but quantitative measures might capture different handedness dimensions and be better suited for genetic analyses. This paper reviews the latest findings from molecular genetic studies as well as the implications of using different ways of assessing handedness.read more
Citations
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GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,P.J. Benke,L.F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,C. deLeeuw,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Bo Jacobsson,Peter K. Joshi,A. Juqessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,K. Kristiansson,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,Gearoid M. McMahon,Pedro Marques-Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Christopher Oldmeadow,K. Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,H. Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,M.J.H.M. van deLoos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Mariza deAndrade,Philip L. DeJager,J.E. deNeve,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Maria Dimitriou,G. Eiriksdottir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Jade Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,W. Hoffmann,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,L. J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,D C Liewald,P. A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,G. Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Dale R. Nyholt,B.A. Oostra,C. N. A. Palmer,Aarno Palotie,B.W.J.H. Penninx,Markus Perola,Patricia A Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,S.M. Ring,Samuli Ripatti,F. Rivadeneira Ramirez,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,B. St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,F.J.A. vanRooij,D.R. vanWagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,J. M. Vonk,G. Waeber,David R. Weir,H. E. Wichmann,E. Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Danielle Posthuma,A.R. Thurik,Nicholas J. Timpson,A.G. Uitterlinden,C.M. vanDuijn,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,Koellinger +201 more
TL;DR: Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
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Cerebral Polymorphisms for Lateralisation: Modelling the Genetic and Phenotypic Architectures of Multiple Functional Modules
TL;DR: The original, monogenic McManus DC (dextral-chance) model of handedness and language dominance is extended to multiple functional modules, and to a polygenic DC model compatible with the molecular genetics ofhandedness, and with the biology of visceral asymmetries found in primary ciliary dyskinesia.
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Insights Into Human and Nonhuman Primate Handedness From Measuring Both Hands
TL;DR: It is concluded that measurement matters in the science of handedness and a candidate behavior for promoting multidisciplinary comparison is role-differentiated bimanual manipulation.
Journal ArticleDOI
Quantitative multidimensional phenotypes improve genetic analysis of laterality traits
TL;DR: This article investigated the heritability of hand, as well as foot, and eye preference by assessing parental effects and SNP-based heritability in the Avon Longitudinal Study of Parents and Children (ALSPAC).
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The development of hand, foot, trunk, hearing, and visual lateral preference throughout the lifespan
TL;DR: The authors investigated the developmental process of five lateral preference dimensions (hand, foot, trunk, hearing, and visual preference) and found a pattern of lateralization strengthening with aging in all the analyzed dimensions.
References
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Journal ArticleDOI
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TL;DR: An association analysis was made of the responses of young adults to a hand-preference questionnaire and it is believed to demonstrate that hand preference is distributed continuously and not discretely.
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