Recent advances in leishmaniasis treatment.
Tatiana Shioji Tiuman,Adriana Oliveira dos Santos,Tânia Ueda-Nakamura,Benedito Prado Dias Filho,Celso Vataru Nakamura +4 more
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TLDR
This review describes the arsenal available for treating Leishmania infections, as well as recent advances from research on plants and synthetic compounds as source drugs for treating the disease, and highlights some biopharmaceutical technologies in the design of the delivery strategy.About:
This article is published in International Journal of Infectious Diseases.The article was published on 2011-08-01 and is currently open access. It has received 289 citations till now. The article focuses on the topics: Cutaneous leishmaniasis.read more
Citations
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Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities.
TL;DR: The various pharmacological and biological activities demonstrated in this review highlight the prospects of nerolidol as a promising chemical or drug candidate in the field of agriculture and medicine.
Journal ArticleDOI
Chalcone Derivatives: Promising Starting Points for Drug Design.
Marcelo N. Gomes,Eugene N. Muratov,Maristela Pereira,Josana de Castro Peixoto,Lucimar Pinheiro Rosseto,Pedro Cravo,Carolina Horta Andrade,Bruno J. Neves,Bruno J. Neves +8 more
TL;DR: This review summarizes current methodological developments towards the design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies (bioisosterism, molecular hybridization, and pro-drug design) and presents successful examples of the use of chalcones.
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Advances in Development of New Treatment for Leishmaniasis.
Juliana Perrone Bezerra de Menezes,Carlos Eduardo Sampaio Guedes,Antonio Luis de Oliveira Almeida Petersen,Deborah Bittencourt Mothé Fraga,Patrícia Sampaio Tavares Veras +4 more
TL;DR: How high-throughput analysis is helping the scientific community to identify novel targets for chemotherapeutic interventions and how this helped to identify and assess the potential of new identified targets is discussed.
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Leishmaniasis drug discovery: recent progress and challenges in assay development.
TL;DR: The in vitro assays currently available have shown poor translational outcomes, with high compound attrition rates, so it is imperative that more physiologically relevant assays are developed to identify anti-leishmanial compounds.
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Cutaneous and mucocutaneous leishmaniasis : Differential diagnosis, diagnosis, histopathology, and management
TL;DR: The diagnosis of leishmaniasis can be challenging because it mimics both infectious and malignant conditions as discussed by the authors, and a misdiagnosis may lead to an unfavorable outcome, and appropriate management requires an accurate diagnosis, which often includes identification of the specific etiologic species.
References
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Biodegradable polymeric nanoparticles based drug delivery systems
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
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Leishmaniasis: current situation and new perspectives.
TL;DR: Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.
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Advances in leishmaniasis.
TL;DR: Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions), and disseminated infection (cutaneous, mucosal, or visceral).
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Plants as source of drugs.
TL;DR: A study of the importance of natural products, especially those derived from higher plants, in terms of drug development, and the main strategies for obtaining drugs from natural sources, fields of knowledge involved, difficulties and perspectives are described.
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Drug Resistance in Leishmaniasis
TL;DR: It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
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