Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers.
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...Phospholipids (soy lecithin and egg lecithin), ionic surfactants (sodium lauryl sulfate, sodium cholate, trimethylammonium bromide and stearylamine), nonionic surfactants (Poloxamer, Span, Pluronic, Tween and Brij), polyvinyl alcohol (PVA) and PEG are the emulsifiers or surfactants commonly used to stabilize the interface between the aqueous medium and the SLN shell (Lin et al. 2017)....
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...…sodium cholate, trimethylammonium bromide and stearylamine), nonionic surfactants (Poloxamer, Span, Pluronic, Tween and Brij), polyvinyl alcohol (PVA) and PEG are the emulsifiers or surfactants commonly used to stabilize the interface between the aqueous medium and the SLN shell (Lin et al. 2017)....
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173 citations
Cites background from "Recent advances in oral delivery of..."
...Focusing on oral administration, despite being considered one of the most proper routes for the administration of medicines, it is not currently an option used in chemotherapy due to the low bioavailability of drugs through this route [34]....
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167 citations
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...Drugs encapsulated in nanocarriers facilitate controlled release, higher bioavailability of drugs and minimum toxicity in comparison to the common drugs used in free form (Vyas et al. 2014; Nasiruddin et al. 2017; Lin et al. 2017)....
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References
1,380 citations
"Recent advances in oral delivery of..." refers background in this paper
...The inclusion of paclitaxel into WGA-coated SLNs led to doubling of MRT in contrast to the control solution....
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...With respect to pharmacokinetics, the drugs in nanocarriers generally revealed prolonged circulation time, increased half-life, reduced clearance, and increased mean residence time (MRT) [5]....
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...In the in vivo pharmacokinetics, theMRTwas found to be 13.9 hours and 9.6 hours for polymer-coated SLNs and aqueous suspension, respectively....
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1,205 citations
"Recent advances in oral delivery of..." refers background in this paper
...epithelial cell monolayer in the GI membrane also contributes to poor permeability for numerous drugs [2]....
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995 citations
"Recent advances in oral delivery of..." refers background in this paper
...[20] Fu PP, Xia Q, Hwang HM, Ray PC, Yu H....
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...The safety of oral nanoformulations is a serious concern for their application [19,20]....
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792 citations
"Recent advances in oral delivery of..." refers background in this paper
...The oral bioavailability of curcumin is less than 1% because this compound has poor aqueous solubility and rapid metabolism [83]....
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742 citations
"Recent advances in oral delivery of..." refers background in this paper
...Researchers focus considerable attention on SLNs as the carriers to protect peptides and proteins known for their sensitivity to various environmental factors such as pH, temperature, and ionic strength [115]....
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