Journal ArticleDOI
Recent advances in oxasteroids chemistry
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TLDR
The continuous interest in the field of oxasteroids mainly arises from the fascinating aspects associated with their peculiar stereochemical features and their promising and sometimes unexpected biological activities.About:
This article is published in Steroids.The article was published on 2007-06-01. It has received 41 citations till now.read more
Citations
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Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities. Applied modifications in the steroidal structure.
A. G. Fragkaki,Yiannis S. Angelis,M.A. Koupparis,Anna Tsantili-Kakoulidou,G. Kokotos,Costas Georgakopoulos +5 more
TL;DR: The structural features of steroids necessary for effective binding to the AR and those which contribute to the stipulation of the androgenic and anabolic activities are presented.
Journal ArticleDOI
Steroids: partial synthesis in medicinal chemistry
TL;DR: The reactions and partial synthesis of estrogens, androgens, pregnanes, bile acid derivatives, cholestanes and vitamin D analogues are covered.
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Nitroalkenes in the synthesis of carbocyclic compounds
TL;DR: The applications of nitroalkenes in the synthesis of small, common and medium ring carbocycles, including natural products are investigated in this paper, where a wide variety of reactions such as Michael addition, Diels-Alder reaction, 1,3-dipolar and cycloaddition, Morita-Baylis-Hillman reaction and many cascade reactions often with high regio- and stereoselectivities.
Journal ArticleDOI
An overview of synthetic approaches for heterocyclic steroids
Ritesh Singh,Gautam Panda +1 more
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Anti-hepatitis B virus constituents from the stem bark of Streblus asper
Jun Li,Jun Li,Yan Huang,Yan Huang,Xin-Lan Guan,Jian Li,Sheng-Ping Deng,Qiang Wu,Yan-Jun Zhang,Yan-Jun Zhang,Xiao-Jian Su,Rui-Yun Yang +11 more
TL;DR: The isolated lignans and allylbenzene derivatives were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line and the most active compounds, magnolol and 9-β-xylopyranosyl-isolariciresinol exhibited significant anti- HBV activities.
References
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Journal ArticleDOI
The Utility of Phosphonate Carbanions in Olefin Synthesis
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Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen
Michael D. Grove,Gayland F. Spencer,W. K. Rohwedder,Nagabhushanam Mandava,Joseph F. Worley,J. David Warthen,G. L. Steffens,Judith L. Flippen-Anderson,J. Carter Cook +8 more
TL;DR: The isolation, structure determination and biological activity of this new plant growth promoter, named (22R, 23R, 24S)-2α-3α,22,23-tetrahydroxy-24-methyl-6,7-s-5α-cholestano-6-7-lactone or brassinolide is reported.
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An improved catalytic OsO4 oxidation of olefins to cis-1,2-glycols using tertiary amine oxides as the oxidant
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Raloxifene (LY139481 HCI) Prevents Bone Loss and Reduces Serum Cholesterol without Causing Uterine Hypertrophy in Ovariectomized Rats
Larry John Black,Masahiko Sato,E R Rowley,D E Magee,A Bekele,D C Williams,G J Cullinan,R Bendele,Raymond F. Kauffman,W R Bensch +9 more
TL;DR: Raloxifene has promise as an agent with beneficial bone and cardiovascular effects in the absence of significant uterine effects, and ethynyl estradiol diverged dramatically from estrogen in its lack of significant estrogenic effects on uterine tissue.
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Organoselenium chemistry. Conversion of ketones to enones by selenoxide syn elimination
TL;DR: In this paper, a-phenyl-seleno ketones were converted to enolates by selenenylation and selenoxide elimination, followed by a-bromination-dehydrobromination.