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Journal ArticleDOI

Recent advances in PVA-polysaccharide based hydrogels and electrospun nanofibers in biomedical applications: A review.

TL;DR: In this paper, modern perspectives of synthesized/developed electrospun nanofibrous hydrogel membranes based popular carbohydrate polymers blend PVA which recently have been employed for versatile biomedical applications particularly wound dressings, were discussed intensively and compared in detail with traditional fabricated membranes based films, as well.
About: This article is published in International Journal of Biological Macromolecules.The article was published on 2021-08-03. It has received 57 citations till now. The article focuses on the topics: Self-healing hydrogels.
Citations
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Journal ArticleDOI
01 Apr 2022-Polymers
TL;DR: In this article , a review of recent progress made in the use of electrospun nanofibers to purify polluted water, wherein the distinctive characteristics of this type of nanofiber are essential when using them to remove organic and inorganic pollutants from wastewater, as well as for oil/water (O/W) separation.
Abstract: Recently, nanofibers have come to be considered one of the sustainable routes with enormous applicability in different fields, such as wastewater treatment. Electrospun nanofibers can be fabricated from various materials, such as synthetic and natural polymers, and contribute to the synthesis of novel nanomaterials and nanocomposites. Therefore, they have promising properties, such as an interconnected porous structure, light weight, high porosity, and large surface area, and are easily modified with other polymeric materials or nanomaterials to enhance their suitability for specific applications. As such, this review surveys recent progress made in the use of electrospun nanofibers to purify polluted water, wherein the distinctive characteristics of this type of nanofiber are essential when using them to remove organic and inorganic pollutants from wastewater, as well as for oil/water (O/W) separation.

25 citations

Journal ArticleDOI
TL;DR: In this paper , the most recent developments of electrospun nanofibers as wound dressings are reviewed, including polymer materials, structure characteristics and the function of promoting wound healing.

19 citations

Journal ArticleDOI
25 Jan 2022-Polymers
TL;DR: Most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration, and combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.
Abstract: The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.

18 citations

Journal ArticleDOI
TL;DR: A recent review as discussed by the authors discusses recent advances in the fabrication and application of biomedical nanofiber hydrogels with a strong emphasis on drug release, showing that a major outcome from these works is that nanofibels can maintain drug release rates exceeding a few days, even extending into months, which is an extremely difficult task to achieve without the nano-texture.
Abstract: Polymer nanofibers have exceptionally high surface area. This is advantageous compared to bulk polymeric structures, as nanofibrils increase the area over which materials can be transported into and out of a system, via diffusion and active transport. On the other hand, since hydrogels possess a degree of flexibility very similar to natural tissue, due to their significant water content, hydrogels made from natural or biodegradable macromolecular systems can even be injectable into the human body. Due to unique interactions with water, hydrogel transport properties can be easily modified and tailored. As a result, combining nanofibers with hydrogels would truly advance biomedical applications of hydrogels, particularly in the area of sustained drug delivery. In fact, certain nanofiber networks can be transformed into hydrogels directly without the need for a hydrogel enclosure. This review discusses recent advances in the fabrication and application of biomedical nanofiber hydrogels with a strong emphasis on drug release. Most of the drug release studies and recent advances have so far focused on self-gelling nanofiber systems made from peptides or other natural proteins loaded with cancer drugs. Secondly, polysaccharide nanofiber hydrogels are being investigated, and thirdly, electrospun biodegradable polymer networks embedded in polysaccharide-based hydrogels are becoming increasingly popular. This review shows that a major outcome from these works is that nanofiber hydrogels can maintain drug release rates exceeding a few days, even extending into months, which is an extremely difficult task to achieve without the nanofiber texture. This review also demonstrates that some publications still lack careful rheological studies on nanofiber hydrogels; however, rheological properties of hydrogels can influence cell function, mechano-transduction, and cellular interactions such as growth, migration, adhesion, proliferation, differentiation, and morphology. Nanofiber hydrogel rheology becomes even more critical for 3D or 4D printable systems that should maintain sustained drug delivery rates.

16 citations

Journal ArticleDOI
TL;DR: In this paper , a three-component chitosan (CS) / sodium alginate (SA) / polyvinyl alcohol (PVA) hydrogel with various weight percentages (0, 5, 10, 15, and 20) wt% of Ag 2 O/SiO 2 with Calendula officinalis flower extract as an active ingredient are fabricated as a novel and green wound dressing.
Abstract: Hydrogels are three-dimensional networks that can absorb moisture up to several times their weight and have many medical and biological applications. In this paper, the fabrication and characterization of a three-component chitosan (CS) / sodium alginate (SA) / polyvinyl alcohol (PVA) hydrogel with various weight percentages (0, 5, 10, 15, and 20) wt% of Ag 2 O/SiO 2 with Calendula officinalis flower extract as an active ingredient are fabricated as a novel and green wound dressing. After forming bio-nano composites utilizing the cross-linking technique, Fourier transform infrared (FT-IR) spectroscopy is applied to determine and prove the functional groups added to the CS/PVA/SA at the whole step. X-ray diffraction (XRD) analysis is performed to prove the crystalline and amorphous structure of Ag 2 O/SiO 2 NPs. The field emission scanning electron microscope (FE-SEM) analyses and Energy-dispersive X-ray spectroscopy (EDS) are performed to confirm the morphology of the composition and check the elements to increase wound healing. Atomic force microscope (AFM) examination is done to prove and determine surface roughness and pores. The tensile test is performed to determine the tensile strength and mechanical properties of nanocomposites. Also, by immersing nanocomposites in the simulated body fluid (SBF) and phosphate buffer salt (PBS), the swelling ratio is determined, and the release of Calendula officinalis flower extract is measured in PBS. Finally, the synthesized hydrogel's water vapor transmission rate (WVRT) and then antibacterial tests are determined. This research proves that with the increase of Ag 2 O/SiO 2 NPs to 20% wt., the biofilm's tensile strength and mechanical properties and all healing properties have improved significantly. Producing these films is very effective in improving skin infections. Finally, the thermogravimetric analysis (TGA) is applied to estimate the thermal stability of the biopolymer films with various percentages of mesoporous Ag 2 O/SiO 2 nanoparticles.

13 citations

References
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Journal ArticleDOI
TL;DR: In this paper, the authors provide an overview of the electrospinning (applied electric field, distance between the needle and collector and flow rate, needle diameter), solution (polymer concentration, viscosity, solvent and solution conductivity) and environmental (relativity humidity and temperature) parameters that affect the nanofibers fabrication.

1,071 citations

Journal ArticleDOI
TL;DR: In this article, the authors present the past and current efforts with a brief description on the featured properties of hydrogel membranes fabricated from biopolymers and synthetic ones for wound dressing applications.

1,059 citations

Journal ArticleDOI
TL;DR: The findings reported here suggest that the PCL NFS is a practical carrier for MSC transplantation, and represents a candidate scaffold for cell-based tissue engineering approaches to cartilage repair.

944 citations

Journal ArticleDOI
TL;DR: The history of dressings from its earliest inception to the current status is traced and the advantage and limitations of the dressing materials are discussed.
Abstract: Wound healing is a dynamic and complex process which requires suitable environment to promote healing process. With the advancement in technology, more than 3000 products have been developed to treat different types of wounds by targeting various aspects of healing process. The present review traces the history of dressings from its earliest inception to the current status and also discusses the advantage and limitations of the dressing materials.

883 citations

Journal ArticleDOI
TL;DR: This study investigated the feasibility of encapsulating human beta-nerve growth factor (NGF), which was stabilized in a carrier protein, bovine serum albumin (BSA) in a copolymer of epsilon-caprolactone and ethyl ethylene phosphate (PCLEEP) by electrospinning to produce biofunctional tissue scaffolds.

568 citations

Trending Questions (1)
What is the easiest way to combine electrospun nanofibers and hydrogels?

The paper does not provide information on the easiest way to combine electrospun nanofibers and hydrogels. The paper discusses the use of electrospun nanofibrous hydrogel membranes based on carbohydrate polymers blend PVA for biomedical applications, particularly wound dressings.