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Recent advances in tissue engineering and anticancer modalities with photosynthetic microorganisms as potent oxygen generators

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TLDR
The current mini-review provides a brief overview of recent developments made with photosynthetic microorganisms, ascertaining their therapeutic capabilities in tissue engineering and anticancer therapy.
Abstract
Adequate oxygen tension has been associated with better tissue regeneration and reversal of tumor cells' resistance against various therapeutic modalities. Over the past two decades, an enormous amount of efforts have been made to develop strategies and materials that could actively generate oxygen to contrast local hypoxia at injury or tumor site. In this context, the current research trend is exploring photosynthetic microorganisms as a continuous oxygenation source. This concise review provides a brief overview of recent developments made with photosynthetic microbes, ascertaining their therapeutic capabilities in tissue engineering and anticancer therapy.

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Engineered herbal scaffolds for tissue repair and regeneration: Recent trends and technologies

TL;DR: An overview of engineered herbal constructs for tissue engineering applications is provided in this paper, where various properties of herbal medicines that are relevant to tissue repair and regeneration are highlighted as well as challenges and outlook for further development and clinical translation of these herbal constructs.
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aNew trends in biotechnological applications of photosynthetic microorganisms.

TL;DR: A review of recent investigations into biomedical, urban, environmental, and electrical engineering microalgae and cyanobacteria applications over the last seven years can be found in this article , where a brief historical outline of advances in photoautotroph-based technologies is presented prior to an exploration of the important role of these microorganisms in combating global warming and food and energy insecurity.
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Photosynthetic Microorganisms for the Oxygenation of Advanced 3D Bioprinted Tissues.

TL;DR: A review of state-of-the-art approaches used to improve oxygen delivery in bioengineered tissues to overcome this challenge is presented in this paper , focusing on the emerging roles played by photosynthetic organisms as novel biomaterials for bioink generation.
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Oxygenation therapies for improved wound healing: current trends and technologies.

TL;DR: The role of oxygen in the wound healing process and different oxygenation therapies that have been applied for healing dermal wounds are overviewed and various challenges and opportunities for adequate and controlled oxygen delivery at the wounded site with minimal toxicity are critically assessed.
References
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Journal ArticleDOI

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

TL;DR: The role of Hypoxia in cancer therapy by regulating the tumor microenvironment (TME) is summarized and the potential of hypoxia-targeted therapy is highlighted to overcome hypoxian-associated resistance in cancer treatment.
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Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment.

TL;DR: Two drugs are in clinical trials to reverse tumor hypoxia; one of these is designed to improve permeability of oxygen into the tumor tissue and the other is based upon a low boiling point FC that transports higher amounts of oxygen per gram than previously tested FCs.
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The impact of hypoxia on tumor-associated macrophages.

TL;DR: A careful characterization and understanding of this macrophage differentiation state is needed in order to efficiently tailor cancer therapy.
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An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

TL;DR: It is hypothesized that regional oxygen treatment by an implanted oxygen-generating depot may enhance the cytotoxicity of DOX against malignant tissues in a highly site-specific manner, without raising systemic oxygen levels, ultimately allaying the hypoxia-induced DOX resistance in solid malignancies.
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The Roles of Hypoxia in the In Vitro Engineering of Tissues

TL;DR: In this paper, the authors address divergent actions of hypoxia in the in vitro generation of clinically relevant tissue-engineered grafts, and better understand the roles of hypoxyia will help prevent common problems and exploit potential benefits of hypoxicia in engineered tissues.
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