Journal ArticleDOI
Recent advances in tRNA mitochondrial import
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TLDR
The characterization of both direct and co-import mechanisms involving distinct protein-import factors is in agreement with a polyphyletic origin of tRNA import.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2008-07-01. It has received 122 citations till now. The article focuses on the topics: TRNA transport & Mitochondrial biogenesis.read more
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Mitochondrial evolution and functions in malaria parasites.
TL;DR: In spite of their minimal nature, Plasmodium mitochondria are attractive targets for antimalarial drugs.
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Mitochondrial tRNA import and its consequences for mitochondrial translation.
TL;DR: Results in plants indicate that direct import of tRNAs may nevertheless require some components of the protein import machinery, which is not trivial and requires unique evolutionary adaptations.
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tRNA Biology in Mitochondria
TL;DR: The specific features of tRNA biology in mitochondria are reviewed from model species representing the major eukaryotic groups, with an emphasis on recent research on tRNA import, maturation and aminoacylation.
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Import of tRNAs and aminoacyl-tRNA synthetases into mitochondria.
TL;DR: All mitochondrial aminoacyl-tRNA synthetases and many tRNAs are imported from the cytosol into the mitochondria in eukaryotic cells and their origin and their import into the organelle have been studied in evolutionary distinct organisms.
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Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes
Trevor Lithgow,André Schneider +1 more
TL;DR: How the processes of protein import and tRNA import relate to each other in an evolutionary context are discussed using a recently revised eukaryotic phylogeny as a framework.
References
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Mitochondrial dna mutations in human disease
TL;DR: This review explores the advances that have been made and the areas in which future progress is likely in understanding basic mitochondrial genetics and the relationship between inherited mutations and disease phenotypes, and in identifying acquired mtDNA mutations in both ageing and cancer.
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Translocation of proteins into mitochondria.
TL;DR: This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research.
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Mitochondrial genomes: anything goes.
TL;DR: In addition to outlining the extraordinary diversity of mtDNA, this review highlights the divergent trends in mitochondrial genome evolution in the various eukaryotic lineages, and examines the relationship between mitochondrial and nuclear genome Evolution in a given organism.
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Prevalence of mitochondrial DNA disease in adults
Andrew M. Schaefer,Robert McFarland,Emma L. Blakely,Langping He,Roger G. Whittaker,Robert W. Taylor,Patrick F. Chinnery,Douglass M. Turnbull +7 more
TL;DR: The aim of this study was to accurately define the prevalence of mtDNA disease (primary mutation occurs in mtDNA) in the working‐age population of the North East of England.
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Evolution of the molecular machines for protein import into mitochondria.
TL;DR: In creating mitochondria some 2 billion years ago, the first eukaryotes needed to establish protein import machinery in the membranes of what was a bacterial endosymbiont, but the protein translocases that drive protein import into mitochondria have no obvious counterparts in bacteria, making it likely that these machines were created de novo.