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Journal ArticleDOI

Recent advances with liposomes as pharmaceutical carriers.

Vladimir P. Torchilin
- 01 Feb 2005 - 
- Vol. 4, Iss: 2, pp 145-160
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TLDR
For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
Abstract
Liposomes — microscopic phospholipid bubbles with a bilayered membrane structure — have received a lot of attention during the past 30 years as pharmaceutical carriers of great potential. More recently, many new developments have been seen in the area of liposomal drugs — from clinically approved products to new experimental applications, with gene delivery and cancer therapy still being the principal areas of interest. For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.

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Citations
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Strategies in the design of nanoparticles for therapeutic applications

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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

TL;DR: PEG is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery and alternative polymers will be evaluated.
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The golden age: gold nanoparticles for biomedicine

TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
References
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Journal ArticleDOI

Cellular uptake of the tat protein from human immunodeficiency virus

TL;DR: Experiments using radioactive protein show that tat becomes localized to the nucleus after uptake and suggest that chloroquine protects tat from proteolytic degradation, raising the possibility that, under some conditions, tat might act as a viral growth factor to stimulate viral replication in latently infected cells or alter expression of cellular genes.
Journal ArticleDOI

Of Theory and Practice

TL;DR: The Essay concludes that practitioners theorize, and theorists practice, use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ.
Journal ArticleDOI

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

TL;DR: The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity.
Journal ArticleDOI

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

TL;DR: It is shown that after an initial ionic cell-surface interaction, TAT-fusion proteins are rapidly internalized by lipid raft–dependent macropinocytosis, and a transducible, pH-sensitive, fusogenic dTAT-HA2 peptide is developed that markedly enhanced Tat-Cre escape from macropinosomes.
Book

Liposomes: From Physics to Applications

TL;DR: Part 1 General Introduction to Liposomes: Chemistry of lipids and liposomes and applications in Basic Sciences and Pharmacology and Medicine.
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