Recent applications of molecular imprinted polymers for enantio-selective recognition.
TL;DR: In this review, progresses in applications of enantio-selective recognition by MIPs will be critically reviewed for the recent period since 2007.
About: This article is published in Talanta.The article was published on 2013-03-15. It has received 82 citations till now. The article focuses on the topics: Molecularly imprinted polymer.
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TL;DR: This review describes the imprinted polymer production processes, the techniques used for reporting, and the applications of the reported sensors, including those designed to detect toxic chemicals, toxins in foods, drugs, explosives, and pathogens.
Abstract: Molecularly imprinted polymers are synthetic receptors for a targeted molecule. As such, they are analogues of the natural antibody–antigen systems. In this review, after a recounting of the early history of the general field, we specifically focus on the application of these polymers as sensors. In these applications, the polymers are paired with a reporting system, which may be electrical, electrochemical, optical, or gravimetric. The presence of the targeted molecule effects a change in the reporting agent, and a calibrated quantity of the target is recorded. In this review, we describe the imprinted polymer production processes, the techniques used for reporting, and the applications of the reported sensors. A brief survey of recent applications to gas-phase sensing is included, but the focus is primarily on the development of sensors for targets in solution. Included among the applications are those designed to detect toxic chemicals, toxins in foods, drugs, explosives, and pathogens. The application...
749 citations
TL;DR: Recent contributions to the understanding of the binding mechanism between chiral selectors and selectands in analytical enantioseparations dating between 2012 and early 2016 including polysaccharide derivatives, cyclodextrins, cyclofructans, macrocyclic glycopeptides, proteins and nucleotide-derived selectors are highlighted.
236 citations
TL;DR: This review surveys selected examples of MIPs used for determining target bioanalytes by mimicking natural recognition, and considers whether these might be considered as alternatives to natural receptors, such as antibodies, enzymes, or histones.
184 citations
Cites background or methods from "Recent applications of molecular im..."
...13 Parathion (an organophosphate herbicide) An MIP film-coated electrode; the functional monomer contained a p-tert-butylcalix[6]-1,4crown-4 moiety DPV 5 nM to 100 mM 1 nM Used for determination of parathion in rice samples; results obtained were similar to those of HPLC [29]...
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...Typically, the resulting MIPs are prepared as bulk polymers, which can then be ground, or, alternatively, they can be prepared as beads of the desired shape and size [5,6]....
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...Another example of supramolecular interactions adopted for imprinting involved the formation of inclusion complexes of phenyl substituent guest moieties with monomers containing calixa[6]rene [29] or cyclodextrin macrocycle host moieties [30,31]....
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Journal Article•
TL;DR: A review of recent contributions to the understanding of the binding mechanism between chiral selectors and selectands in analytical enantioseparations dating between 2012 and early 2016 can be found in this article.
158 citations
TL;DR: This review paper focusses on the latest development of MIPs for the analysis of personal care products in the environment, with particular emphasis on design, preparation and practical applications of M IPs.
121 citations
Cites background from "Recent applications of molecular im..."
...Experts believe that in a near future MIP based sensors will compete with analytical techniques like liquid chromatography, mass spectrometry, spectroscopic methods among others [60]....
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References
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TL;DR: The focus of this article is to review molecular imprinting within hydrogels and discuss recent efforts on analyte-responsive intelligent gels, specifically suggesting the possibility of utilizing molecular imprinted strategies to impart analyte specificity and responsiveness within these systems.
1,111 citations
TL;DR: Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.
Abstract: Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.
804 citations
TL;DR: This critical review describes many methods used for imprinting recognition for protein targets in polymers and their incorporation with a number of transducer platforms with the aim of identifying the most promising approaches for the preparation of MIP-based protein sensors.
Abstract: The detection of specific proteins as biomarkers of disease, health status, environmental monitoring, food quality, control of fermenters and civil defence purposes means that biosensors for these targets will become increasingly more important. Among the technologies used for building specific recognition properties, molecularly imprinted polymers (MIPs) are attracting much attention. In this critical review we describe many methods used for imprinting recognition for protein targets in polymers and their incorporation with a number of transducer platforms with the aim of identifying the most promising approaches for the preparation of MIP-based protein sensors (277 references).
618 citations
TL;DR: In this article, the authors present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprintings methods but with little or no prior experience in polymer synthesis.
Abstract: Hongyuan Yan and Kyung Ho Row* Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon, 402–751, Korea * Corresponding author. E-mail: rowkho@inha.ac.kr Received: 12 April 2006 / Accepted: 27 June 2006 / Published: 29 June 2006 Abstract: Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity to the predetermined molecule (template) are now seeing a fast growing research. However, optimization of the imprinted products is difficult due to the fact that there are many variables to consider, some or all of which can potentially impact upon the chemical, morphological and molecular recognition properties of the imprinted materials. This review present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. The synthesis, characteristic, effect of molecular recognition and different preparation methods of MIP in recent few years are discussed in this review, unsolved problems and possible developments of MIP were also been briefly discussed. Keywords: molecularly imprinted polymer, special molecular recognition, synthetic approach 1. Molecular Imprinting Technology Molecular imprinting technology is a rapidly developing technique for the preparation of polymers having specific molecular recognition properties for a given compound, its analogues or for a single enantiomer [1-3]. Synthesis of MIP is a relatively straightforward and inexpensive procedure. In short, the molecularly imprinted polymer is prepared by mixing the template molecule with functional monomers, cross-linking monomers and a radical initiator in a proper solvent, most often an aprotic and non polar solvent. Subsequently, this pre-polymerization mixture is irradiated with UV light or
447 citations
TL;DR: New synthetic conditions are initiated to obtain MIP beads with controllable size in the nano- to micro-meter range, using racemic propranolol as a model template, and the imprinted sites displayed high chiral selectivity.
387 citations