Recent development in transition metal-catalysed C–H olefination
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This review has summarized the recent progress in the oxidative olefination of sp2 and sp3 C–H bonds with special emphasis on distal, atroposelective, non-directed sp 2 and directed sp3 c–H oleFination.Abstract:
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of directing groups, catalysts and ligands has played a crucial role in selective C–H bond (sp2 or sp3) activation. Recent developments in these areas have assured a high level of regioselectivity in C–H olefination reactions. In this review, we have summarized the recent progress in the oxidative olefination of sp2 and sp3 C–H bonds with special emphasis on distal, atroposelective, non-directed sp2 and directed sp3 C–H olefination. The scope, limitation, and mechanism of various transition metal-catalysed olefination reactions have been described briefly.read more
Citations
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C-H deuteration of organic compounds and potential drug candidates.
TL;DR: This review summarises deuteration methods of various organic motifs containing C(sp2)-H and C( sp3)-H bonds utilizing C-H bond functionalisation as a key step along with a variety of catalysts, and exemplifies their biological relevance.
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Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites
TL;DR: In this paper , a photoredox catalytic system is proposed for C(sp2)-H olefination, which combines a merger of palladium/organo-photocatalyst (PC) with visible light.
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C–H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives
TL;DR: In this article, the authors have demonstrated the existing trends in the C-H functionalization methodology using high-valent cobalt catalysis and highlighted the main challenges to overcome, as well as perspective directions which need to be further developed in the future.
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Asymmetric synthesis of chiral organosilicon compounds via transition metal-catalyzed stereoselective C-H activation and silylation.
TL;DR: In this paper, the progress of transition metal-catalyzed stereoselective sp2 and sp3 C-H activation and silylation in the synthesis of chiral organosilicon compounds is discussed.
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Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C-H Annulation and Their Application to Pd-Catalyzed Aerobic C-H Alkenylation.
TL;DR: In this article, a new class of bidentate ligands was prepared by a modular approach involving Rh-catalyzed C-H annulation reactions, and the resulting conformationally constrained ligands enabled electron-rich and sterically less hindered positions of electron rich arenes while promoting the facile oxidation of Pd(0) intermediates by oxygen.
References
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Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
TL;DR: This review focuses on Rh-catalyzed methods for C-H bond functionalization, which have seen widespread success over the course of the last decade and are discussed in detail in the accompanying articles in this special issue of Chemical Reviews.
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Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.
TL;DR: This review summarizes the development and scope of carboxylates as cocatalysts in transition-metal-catalyzed C-H functionalizations until autumn 2010 and proposes new acronyms, such as CMD (concerted metalationdeprotonation), IES (internal electrophilic substitution), or AMLA (ambiphilic metal ligand activation), which describe related mechanisms.
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Synthesis of Light-Emitting Conjugated Polymers for Applications in Electroluminescent Devices
TL;DR: School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Victoria 3010, Australia; School of Materials Science and Engineering, Nanyang Technological University, Nastyang Avenue, Republic of Singapore 639798; Institute of Materials Research and Engineering (IMRE) and the Agency for Science, Technology and Research (A*STAR), 3 Research Link, Singapore 117602.
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Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions.
TL;DR: The motivation for studying Pd-catalyzed C-H functionalization assisted by weakly coordinating functional groups is discussed, and efforts to bring reactions of this type to fruition are chronicle.
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C-H bond activation enables the rapid construction and late-stage diversification of functional molecules
TL;DR: This Perspective highlights the potential of metal-catalysed C-H bond activation reactions, which now extend beyond the field of traditional synthetic organic chemistry, and are more atom- and step-economical than previous methods.