Journal ArticleDOI
Recent Developments in the Ferrier Rearrangement
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TLDR
A review of recent developments in the use of promoters for the Ferrier rearrangement of O-, N-, C- and S-nucleophiles with glycals can be found in this paper.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2013-11-01. It has received 121 citations till now. The article focuses on the topics: Ferrier rearrangement & Ferrier carbocyclization.read more
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Palladium(0)-catalysed synthesis of 2,3- and 3,4-unsaturated aryl β-O-glycosides.
TL;DR: Arylation of 6-O-tert-butyldiphenylsilyl-3,4-di- O-isobutyloxycarbonyl-d-glucal with various phenols in the presence of a catalytic amount of palladium gave the corresponding 2,3- and 3, 4-unsaturated β-O -glycosides.
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Ferrier–Nicholas Cations from C-3-Alkynylglycals: Access to C-3-Branched Allylic Glycosides and Ring-Opening Derivatives
TL;DR: The authors of as mentioned in this paper are grateful to the Ministerio de Economia y Competitividad for grants CTQ2012-32114 and CTQ2015-66702-R. L. and S. M.
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Reaction of Glycals with Organic Peroxides: Synthesis of 2-iodo, 2-Deoxy and 2,3-Unsaturated Glycosides
Faheem Rasool,Faheem Rasool,Aabid H. Bhat,Nazar Hussain,Nazar Hussain,Debaraj Mukherjee,Debaraj Mukherjee +6 more
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Synthesis of 3-S- and 3-Se-glycals by using R-S-S-R and R-Se-Se-R as the nucleophile precursors promoted by Hf(OTf)4 and the temperature-dependent formation of the above-mentioned 3-S- and 3-Se products
TL;DR: In this paper, a temperature-dependent profile of the yield of these two products is given, and a temperature dependent profile of C-1-S/Se and C-3-S /Se product is given.
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β-C-Glycosylation with 2-Oxindole Acceptors via Palladium-Catalyzed Decarboxylative Reactions.
TL;DR: This report describes a highly efficient β-selective C-glycosylation of bicyclic galactals with 2-oxindoles through a palladium-catalyzed decarboxylative pathway that could serve as an efficient base to deprotonate the enol tautomer of 2-Oxindole and enhance its nucleophilicity.
References
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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
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The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
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The growing impact of click chemistry on drug discovery.
TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
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Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen
TL;DR: In this paper, the authors show how in der Natur am haufigsten vorkommenden Verbindungen, so fallt auf, dass the Bildung von Kohlenstoff-Heteroatom-Bindungen gegenuber der von KHO-Kohlenstoffs-KHO-Bindingsen deutlich bevorzugt is, and das Medium naturlicher Reaktionen zumeist Wasser ist.
Journal ArticleDOI
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
TL;DR: An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of experimental results, particularly the various methods of catalyst generation, solvent and substrate effects, and choice of base or ligand as discussed by the authors.
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