Recent progress in Lynch syndrome and other familial colorectal cancer syndromes.
Citations
205 citations
84 citations
81 citations
67 citations
64 citations
References
6,883 citations
6,835 citations
6,215 citations
"Recent progress in Lynch syndrome a..." refers background in this paper
...Tumor mutational burden appears to be a potential predictor across cancers on the whole, although the predictive power of mutational load calculation is not clear within the confines of the hypermutated subset of cancers (MSI and DNA polymerase-proofreading mutated).(138,139) Early data suggest that disparities in mutational load cannot predict the differential effects of PD-1 inhibition among MSI CRCs....
[...]
4,948 citations
4,612 citations
"Recent progress in Lynch syndrome a..." refers background in this paper
...PD-1 inhibition has largely gained traction, not because it was the first exploitable target of this type but, rather, because of its greater efficacy and tolerability compared with monotherapy CTLA-4 blockade.(144) As multiple drugs targeting these processes come into clinical use, such combinatorial approaches are well within reach....
[...]