Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
Citations
366 citations
269 citations
Cites background or result from "Recent publications from the Alzhei..."
...This may be due to the inclusion of subjects with SNAP or isolated Ab pathology (IAP) that is likely either an early stage in which neuronal injury has not yet been seen or another amyloid-related disease....
[...]
...The efficacy of multimodal classification is well established [7], but the simultaneous measurement of all biomarkers required for this approach is time consuming, costly, and invasive....
[...]
...The view of AD as a disconnection syndrome in which brain regions become successively disconnected both structurally and functionally during the course of AD disease progression is now well established with considerable evidence to support it [7]....
[...]
...As hypertension, high cholesterol, and diabetes have long been recognized as AD risk factors [7], the question of howvascular burden affectsADdisease progression is of paramount importance....
[...]
..., [10]) which then have hinted at highly complex multifactorial mechanisms underlying AD disease progression [7]....
[...]
194 citations
175 citations
171 citations
References
12,652 citations
"Recent publications from the Alzhei..." refers background in this paper
...The amyloid cascade hypothesis [256] has dominated research over the last two decades, to the point that diagnostic criteria for AD now include Ab abnormalities....
[...]
9,700 citations
"Recent publications from the Alzhei..." refers background in this paper
...generate measures (strength, weighted local efficiency, weighted clustering coefficient, and characteristic path length) that describe the organization of the network [319,320]....
[...]
5,671 citations
"Recent publications from the Alzhei..." refers background in this paper
...The importance of Ab status is underscored by its inclusion in the revised diagnostic criteria for AD [123] and by its use in the selection of asymptomatic subjects likely to progress for therapeutic clinical trials....
[...]
3,953 citations
"Recent publications from the Alzhei..." refers background in this paper
...Knowledge of disease progression has guided this development; the effectiveness of established biomarkers at diagnostic and prognostic challenges reflects their position in the temporal ordering of biomarkers as described by the first model of the pathological cascade [482]....
[...]