Recombinant human decorin inhibits TGF-β1-induced contraction of collagen lattice by hypertrophic scar fibroblasts
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...Zhang and colleagues (78) showed similar results, with decorin inhibiting both the basal and TGF-β1–enhanced contraction of collagen gel by both normal and hypertrophic scar fibroblasts, suggesting that decorin may have therapeutic potential for excessive skin contraction as observed in hypertrophic scarring....
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...gen gel by keloid fibroblasts.(41) In human normal skin and hypertrophic...
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...b1 and neutralize some of its activity.(41,42) Also, decorin...
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Cites background from "Recombinant human decorin inhibits ..."
...Stimulation of contraction caused by thrombospondin and inhibition of contraction caused by decorin have been linked to the ability of these matrix components to modify the availability of transforming growth factor β (TGFβ) (Sakai et al. 2003, Zhang et al. 2009)....
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