Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration
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Cites background from "Reconstruction of Gene Regulatory M..."
...Inferring GRNs remain challenging because of several limitations: (1) the high dimensionality of living cells is where tens of thousands of genes act at different temporal and spatial combinations; (2) one gene or gene product may interact with multiple partners, either directly or indirectly and thus possible relationships are dynamic and nonlinear; (3) current high-throughput technologies generate data that involve a substantial amount of noise [9, 12]; (4) the sample size is extremely low compared with the number of genes [13, 14] and the presence of hidden nodes [9]....
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References
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"Reconstruction of Gene Regulatory M..." refers methods in this paper
...The mgeneSim function of the SemSim Package of Bioconductor [53] was used to perform this function....
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"Reconstruction of Gene Regulatory M..." refers methods in this paper
...From the time course gene expression data, 846 genes were previously identified as cell cycle regulated based on analysis combining a Fourier algorithm and a correlation algorithm [50]....
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"Reconstruction of Gene Regulatory M..." refers background in this paper
...Coordinately expressed genes are likely to be unified by common cis-regulatory elements and their cognate transcription factor(s) [31,32] but this relationGene Regulatory Modules...
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