Recovery of laryngeal function after intraoperative injury to the recurrent laryngeal nerve
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This review aims to provide an update on the current understandings of surgically-induced injury to the laryngeal nerves to clarify any differences between the transient and permanent injury of the RLN.Abstract:
Loss of function in the recurrent laryngeal nerve (RLN) during thyroid/parathyroid surgery, despite a macroscopically intact nerve, is a challenge which highlights the sensitivity and complexity of laryngeal innervation. Furthermore, the uncertain prognosis stresses a lack of capability to diagnose the reason behind the impaired function. There is a great deal of literature considering risk factors, surgical technique and mechanisms outside the nerve affecting the incidence of RLN paresis during surgery. To be able to prognosticate recovery in cases of laryngeal dysfunction and voice changes after thyroid surgery, the surgeon would first need to define the presence, location, and type of laryngeal nerve injury. There is little data describing the events within the nerve and the neurobiological reasons for the impaired function related to potential recovery and prognosis. In addition, very little data has been presented in order to clarify any differences between the transient and permanent injury of the RLN. This review aims, from an anatomical and neurobiological perspective, to provide an update on the current understandings of surgically-induced injury to the laryngeal nerves.read more
Citations
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Neuromuscular blockade management for intraoperative neural monitoring.
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Automated Quantification of Vocal Fold Motion in a Recurrent Laryngeal Nerve Injury Mouse Model
TL;DR: VF motion dynamics after iatrogenic recurrent laryngeal nerve injury in a mouse surgical model is examined to identify a method of inducing injury with a consistent recovery pattern from which to evaluate spontaneous recovery and test therapeutic interventions.
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A Surgical Mouse Model for Advancing Laryngeal Nerve Regeneration Strategies
Alexis Mok,Jakob Allen,Megan M Haney,Ian Deninger,Brayton Ballenger,Victoria Caywood,Kate L Osman,Bradford P. Zitsch,Bridget L. Hopewell,Aaron Thiessen,Marlena Szewczyk,Daniel Ohlhausen,Christopher Ian Newberry,Emily Leary,Teresa E. Lever +14 more
TL;DR: A mouse model of iatrogenic RLN injury with impaired VF mobility and swallowing function is successfully developed that can serve as a clinically relevant platform to develop translational neuroregenerative strategies for RLN regenerative strategies.
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Guidelines for the management of unilateral vocal fold paralysis from the Korean society of laryngology, phoniatrics and logopedics
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References
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Degeneration and regeneration of the nervous system
Book
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James W. Fawcett,Roger J. Keynes +1 more
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