Redox control of senescence and age-related disease
Reads0
Chats0
TLDR
The known biological theories of aging are reviewed and how ROS mechanistically control senescence and the aging process are described and the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases are described.Citations
More filters
Journal Article
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
TL;DR: Coppe et al. as mentioned in this paper showed that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy, including interleukin (IL)-6 and IL-8.
Journal ArticleDOI
Oxidative stress, aging, and diseases.
Ilaria Liguori,Gennaro Russo,Francesco Curcio,Giulia Bulli,Luisa Aran,David Della-Morte,Gaetano Gargiulo,Gianluca Testa,Gianluca Testa,Francesco Cacciatore,Domenico Bonaduce,Pasquale Abete +11 more
TL;DR: Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions.
Journal ArticleDOI
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Ruchi Kumari,Parmjit S Jat +1 more
TL;DR: In this article, the molecular mechanisms that underlie cellular senescence and the senescent associated growth arrest with a particular focus on why cells stop dividing, the stability of the growth arrest, the hypersecretory phenotype and how the different pathways are all integrated.
Journal ArticleDOI
Role of p53 in the Regulation of Cellular Senescence
TL;DR: The p53-mediated regulation of several pathophysiological microenvironments that could be associated with senescence and its development are discussed, including the surrounding tissue microenvironment and the neighboring cells by secreting pro-inflammatory cytokines.
Journal ArticleDOI
Hallmarks of senescence and aging.
TL;DR: It is considered that the telomere length is the weak biomarker (with poor predictive accuracy), and there is currently no reliable biomarker that meets all the necessary criteria.
References
More filters
Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
Journal ArticleDOI
TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.