Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
Citations
2,507 citations
Cites background from "Reduced Incidence of Prevotella and..."
...Indeed, dysbiosis of the microbiota is implicated in the pathogenesis of several human disorders, including IBD, obesity, and cardiovascular disease (Blumberg and Powrie, 2012), and several studies report altered composition of the intestinal microbiota in ASD (Adams et al., 2011; Finegold et al., 2010; Finegold et al., 2012; Kang et al., 2013; Parracho et al., 2005;Williams et al., 2011; Williams et al., 2012)....
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...…D’Eufemia et al., 1996; de Magistris et al., 2010) and microbiome alterations (Adams et al., 2011; Finegold C et al., 2010; Finegold et al., 2012; Kang et al., 2013; Parracho et al., 2005; Williams et al., 2011; Williams et al., 2012) are reported in several independent studies of ASD; however,…...
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...…and cardiovascular disease (Blumberg and Powrie, 2012), and several studies report altered composition of the intestinal microbiota in ASD (Adams et al., 2011; Finegold et al., 2010; Finegold et al., 2012; Kang et al., 2013; Parracho et al., 2005;Williams et al., 2011; Williams et al., 2012)....
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2,436 citations
2,184 citations
Cites background from "Reduced Incidence of Prevotella and..."
...In many cases researchers have also failed to repeat the random subsampling step or record the pseudorandom number generation seed/process — both of which are essential for reproducibility....
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1,359 citations
1,325 citations
Cites background from "Reduced Incidence of Prevotella and..."
...However, low Prevotellaceae levels do not seem to be specific for PD, because they have been reported in patients with autism and type 1 diabetes.(61,71) Based on these observations, high fecal abundance of Prevotellaceae could be a useful biomarker to exclude PD....
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...Decreased levels of Prevotella and increased abundance of Enterobacteriaceae in feces of autistic children support the relevance of these bacteria in CNS disorders.(61,62) Prevotella is a commensal microbe in the colon that not only can degrade a broad spectrum of plant polysaccharides and mucin glycoproteins in the mucosal layer of the gut, but also may interact with the immune system....
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...Prevotella is a commensal microbe in the colon that not only can degrade a broad spectrum of plant polysaccharides and mucin glycoproteins in the mucosal layer of the gut, but also may interact with the immune system.(61,63-65) Prevotella is the main contributor of one of the recently suggested gut microbiome enterotypes....
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References
28,911 citations
"Reduced Incidence of Prevotella and..." refers methods in this paper
...We measured phylogenetic diversity (PD) index by using Quantitative Insights Into Microbial Ecology (QIIME) software package [29]....
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17,350 citations
"Reduced Incidence of Prevotella and..." refers methods in this paper
...We denoised PCR artifacts by eliminating sequences with low qualities [25]....
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...We used the Mothur software to obtain rarefaction curves and ecological indices of Chao1 estimator and Shannon diversity/ richness [25]....
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17,301 citations
"Reduced Incidence of Prevotella and..." refers methods in this paper
...To obtain the operational taxonomic units (OTUs), we clustered the sequencing readouts at 90, 95, and 97% similarity with UCLUST algorithm [28], which are roughly equivalent to the taxonomic terms of family, genus, and species, respectively....
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...We randomly subsampled the lowest number (15,991 sequence reads per sample) ten times, combined all sequences, and clustered sequences at 90, 95, and 97 % similarity by using UCLUST algorithm (Edgar 2010)....
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14,830 citations
"Reduced Incidence of Prevotella and..." refers methods in this paper
...adjust for multiple testing correction; glm for logistic regression; the glmperm package for permutation test for regression [34]; the randomForest package for Random Forests classification [35])....
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9,268 citations
"Reduced Incidence of Prevotella and..." refers background in this paper
...[47] found 25 percent fewer genes in the gut of patients with irritable bowel syndrome than in healthy controls....
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