Reduction in oxidatively generated DNA damage following smoking cessation.
Harold C. Box,Richard J O'Connor,Helen B. Patrzyc,Herbert Iijima,Jean B. Dawidzik,Harold G. Freund,Edwin E. Budzinski,K. Michael Cummings,Martin C. Mahoney +8 more
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TLDR
Results from this analysis suggest that cigarette smoking contributes to oxidatively induced DNA damage, and that smoking cessation appears to reduce levels of specific damage markers between 30-50 percent in the short term.Abstract:
Background
Cigarette smoking is a known cause of cancer, and cancer may be in part due to effects of oxidative stress. However, whether smoking cessation reverses oxidatively induced DNA damage unclear. The current study sought to examine the extent to which three DNA lesions showed significant reductions after participants quit smoking.read more
Citations
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Smoking and increased Alzheimer's disease risk: A review of potential mechanisms
Timothy C. Durazzo,Timothy C. Durazzo,Niklas Mattsson,Niklas Mattsson,Niklas Mattsson,Michael W. Weiner +5 more
TL;DR: Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD), which is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians.
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Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
TL;DR: The continuing development and improvement of LC-MS/MS coupled with the stable isotope-dilution method for DNA adduct quantification will further promote research about the clinical implications and diagnostic applications of oxidatively induced DNAAdducts.
Journal ArticleDOI
Mononuclear leukocyte DNA damage and oxidative stress: the association with smoking of hand-rolled and filter-cigarettes.
TL;DR: It is indicated that smoking of hand-rolled cigarettes has stronger genotoxic and oxidative effects on the metabolism than smoking of manufactured filter-cigarettes, and it is proposed that these harmful effects could be attributed to the higher level of oxidants.
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Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Sheetal Hardikar,Sheetal Hardikar,Xiaoling Song,Rosa Ana Risques,Thomas J. Montine,Catherine Duggan,Patricia L. Blount,Patricia L. Blount,Brian J. Reid,Garnet L. Anderson,Garnet L. Anderson,Mario Kratz,Mario Kratz,Emily White,Emily White,Thomas L. Vaughan,Thomas L. Vaughan +16 more
TL;DR: Increasing age, male gender, smoking history, and sTNF-RI levels were associated with short LTL among persons with BE but no correlations were observed between LTL and other inflammatory markers or measures of obesity.
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The influence of active and passive smoking during pregnancy on umbilical cord blood levels of vitamins A and E and neonatal anthropometric indices
Olga E. Titova,Elena A. Ayvazova,Fatima A. Bichkaeva,Samantha J. Brooks,Galina N. Chumakova,Helgi B. Schiöth,Christian Benedict +6 more
TL;DR: An inverse association between smoking behaviour during pregnancy and birth length was observed, with shortest length in active smokers followed by passive smoking mothers, and the observed increase in umbilical cord serum levels of vitamins A and E may subserve antioxidative processes in response to tobacco smoke-induced oxidative stress.
References
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Journal ArticleDOI
Longitudinal data analysis using generalized linear models
Kung Yee Liang,Scott L. Zeger +1 more
TL;DR: In this article, an extension of generalized linear models to the analysis of longitudinal data is proposed, which gives consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
The Health Consequences of Smoking: A Report of the Surgeon General
TL;DR: This new report of the Surgeon General on the health effects of smoking provides a startling picture of the damage to health caused by tobacco use as discussed by the authors, and tragically this injury often leads to incurable disease and death.
Journal ArticleDOI
Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
Journal ArticleDOI
Role of oxygen radicals in DNA damage and cancer incidence
TL;DR: The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants.