Reflex Regulation of Arterial Pressure during Sleep in Man: A Quantitative Method of Assessing Baroreflex Sensitivity
Reads0
Chats0
TLDR
It is concluded that the baroreceptor reflex are can be rapidly reset, particularly during sleep, and the lower arterial pressures during sleep may be actively maintained in some subjects by increased baroreflex sensitivity.Abstract:
The control of arterial pressure during sleep was studied in 13 untreated, unsedated subjects aged 20 to 46, including 7 with hypertension. Arterial pressure was measured directly. A transient rise of arterial pressure up to 30 mm Hg was produced by the sudden intravenous injection of 0.25 to 2 µg of angiotensin. Linear plots were obtained in 10 of 13 subjects when the systolic pressures of successive pulses during the pressure rise were plotted against the pulse intervals which began the next beat. The relationship was disturbed by movement or arousal, and was better when pulse intervals falling in inspiration were discarded. The slope of the line (milliseconds of cardiac slowing per millimeter rise in systolic pressure) in the awake subject ranged from 2 to 15.5 msec/mm Hg, and from 4.5 to 28.9 during sleep. Reflex sensitivity was highest in dreaming sleep. In 7 of 10 subjects, baroreflex sensitivity increased significantly during sleep; in 6, the prevailing arterial pressure was inversely correlated wi...read more
Citations
More filters
Journal ArticleDOI
Cardiovascular neural regulation explored in the frequency domain.
TL;DR: It is the opinion that rhythms and neural components always interact, just like flexor and extensor tones or excitatory and inhibitory cardiovascular reflexes, and that it is misleading to separately consider vagal and sympathetic modulations of heart rate.
Journal ArticleDOI
Sympathetic-Nerve Activity during Sleep in Normal Subjects
TL;DR: REM sleep is associated with profound sympathetic activation in normal subjects, possibly linked to changes in muscle tone and the hemodynamic and sympathetic changes during REM sleep could play a part in triggering ischemic events in patients with vascular disease.
Journal ArticleDOI
Effect of age and high blood pressure on baroreflex sensitivity in man.
TL;DR: Eight subjects who had normal blood pressure at the time of testing but whose pressure had been elevated in the past, had reflex sensitivities significantly less than expected in persons of the same age and mean arterial pressure.
Journal ArticleDOI
Chronic Rapid Atrial Pacing Structural, Functional, and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation
TL;DR: In this article, two-dimensional echocardiography was performed in 11 dogs to assess the effects of rapid atrial pacing on atrial size, which was defined as the ability to induce sustained repetitive atrial responses during programmed electrical stimulation and was assessed by extrastimulus and burst-pacing techniqu...
Journal ArticleDOI
Defective cardiac parasympathetic control in patients with heart disease.
TL;DR: Baroreceptor-induced slowing of heart rate in normal subjects was shown to be mediated by the parasympathetic nervous system since it could be abolished with atropine.
References
More filters
Journal ArticleDOI
Reflexogenic Areas of the Cardiovascular System
TL;DR: Experiments done between 1877 and 1926 showed that a rise of blood pressure in the carotid-cephalic circulation induces bradycardia and a fall of the systemic arterial pressure, while a drop in the vehicle pressure provokes acceleration of the heart rate and a rise in the systemicarterial pressure.
Journal ArticleDOI
Research on the neural structures and responsible mechanisms in different phases of physiological sleep.
Journal ArticleDOI
The action of peptides on the adrenal medulla. release of adrenaline by bradykinin and angiotensin.
W. Feldberg,G. P. Lewis +1 more
TL;DR: The present experiments show that bradykinin and angiotensin are potent releasers of the medullary hormones, probably mainly adrenaline, from the suprarenal glands, and ang Elliotensin is more potent in this respect than any other known substance.
Journal ArticleDOI
A mathematical model of heart rate control by sympathetic and vagus efferent information
Homer R. Warner,Albert Cox +1 more
TL;DR: The effect on heart rate of stimulation of sympathetic and vagus efferent nerves to the heart has been described in a qualitative fashion by many investiga tors as discussed by the authors, except for the work of Rosenblueth and Simeone1 in 1934.