Journal ArticleDOI
Regiodivergent CDC reactions of aromatic aldehydes with unactivated arenes controlled by transient directing strategy.
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TLDR
In this article, transient directing group controlled regiodiveriverivergent C(sp3)-C(sp2) cross-coupling in the o-methyl benzaldehyde frameworks is reported.About:
This article is published in Chemical Communications.The article was published on 2021-10-26. It has received 4 citations till now. The article focuses on the topics: Benzaldehyde.read more
Citations
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Journal ArticleDOI
PdII-Catalyzed Site-selective β- and γ-C(sp3)-H Arylation of Primary Aldehydes Controlled by Transient Directing Groups.
TL;DR: Pd(II)-catalyzed site-selective β- and γ-C(sp3)-H arylation of primary aldehydes is developed by rational design of L,X-type transient directing groups (TDG) as discussed by the authors .
Journal ArticleDOI
Chemodivergent Synthesis of Indeno[1,2-b]indoles and Isoindolo[2,1-a]indoles via Mn(III)-Mediated or Electrochemical Intramolecular Radical Cross-Dehydrogenative Coupling.
TL;DR: Plausible mechanisms of the chemodivergent reactions were proposed and Mn(OAc)3·2H2O selectively promoted an intramolecular radical C-H/C-H dehydrogenative coupling reaction to provide indeno[1,2-b]indole and isoindolo[2,1-a]indoles.
Journal ArticleDOI
Palladium‐catalyzed Atroposelective Interannular C‐H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy
TL;DR: In this article , a concise synthesis of axially chiral biaryl aldehydes through Pd/amino acid-catalyzed atroposelective interannular C−H arylation of aryl iodides is developed.
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ortho-C(sp3)-H arylation of aromatic aldehydes using 2-amino-N-methyl-acetamide as a L,L-type transient directing group.
TL;DR: Pd-catalyzed ortho-C(sp3)-H arylation of aromatic aldehydes using 2-amino-N-methylacetamide as a simple, efficient and commercially available L,L-type transient directing group (TDG) is reported in this article .
References
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Journal ArticleDOI
Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds
Charles S. Yeung,Vy M. Dong +1 more
Journal ArticleDOI
Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis
TL;DR: The emergence of transient directing group approaches through the in situ installation and deconstruction of a Lewis-basic entity with the aid of co-catalytic additives for selective C–H functionalizations is discussed.
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Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.
TL;DR: S sulfonamide directing groups demonstrate that the auxiliary approach established in asymmetric catalysis can be equally effective in developing broadly useful C-H activation reactions.
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Transition metal-catalyzed site- and regio-divergent C–H bond functionalization
TL;DR: This review describes recent advances in transition metal-catalyzed divergent C-H bond functionalization that highlight its potential in organic synthesis.
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Pd(II)-catalyzed ortho- or meta-C-H olefination of phenol derivatives.
TL;DR: A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives, and the meta-C-H functionalization of electron-rich Phenol derivatives is unprecedented.