Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition).

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Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition).

Journal Article•DOI•

Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition).

Terese T. Horlocker¹, Denise J. Wedel¹, John C. Rowlingson², F. Kayser Enneking³, Sandra L. Kopp¹, Honorio T. Benzon⁴, David L. Brown⁵, John A. Heit¹, Michael F. Mulroy⁶, Richard W. Rosenquist⁷, Michael Tryba, Chun-Su Yuan⁸ - Show less +8 more•Institutions (8)

Mayo Clinic¹, University of Virginia², University of Florida³, Northwestern University⁴, Cleveland Clinic⁵, Virginia Mason Medical Center⁶, University of Iowa⁷, University of Chicago⁸

01 Jan 2010-Regional Anesthesia and Pain Medicine (Lippincott Williams and Wilkins)-Vol. 35, Iss: 1, pp 64-101

TL;DR: The ASRA consensus statements represent the collective experience of recognized experts in the field of neuraxial anesthesia and anticoagulation and are based on case reports, clinical series, pharmacology, hematology, and risk factors for surgical bleeding.

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About: This article is published in Regional Anesthesia and Pain Medicine.The article was published on 2010-01-01. It has received 1319 citations till now. The article focuses on the topics: Neuraxial blockade & Anesthesiology.

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TL;DR: Current recommendations about the prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer and oncology professionals should educate patients about the signs and symptoms of VTE.

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Abstract: Purpose To provide current recommendations about the prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer.

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Abstract: L. David Hillis, MD, FACC, Chair†; Peter K. Smith, MD, FACC, Vice Chair*†; Jeffrey L. Anderson, MD, FACC, FAHA*‡; John A. Bittl, MD, FACC§; Charles R. Bridges, MD, SCD, FACC, FAHA*†; John G. Byrne, MD, FACC†; Joaquin E. Cigarroa, MD, FACC†; Verdi J. DiSesa, MD, FACC†; Loren F. Hiratzka, MD, FACC, FAHA†; Adolph M. Hutter, Jr, MD, MACC, FAHA†; Michael E. Jessen, MD, FACC*†; Ellen C. Keeley, MD, MS†; Stephen J. Lahey, MD†; Richard A. Lange, MD, FACC, FAHA†§; Martin J. London, MD ; Michael J. Mack, MD, FACC*¶; Manesh R. Patel, MD, FACC†; John D. Puskas, MD, FACC*†; Joseph F. Sabik, MD, FACC*#; Ola Selnes, PhD†; David M. Shahian, MD, FACC, FAHA**; Jeffrey C. Trost, MD, FACC*†; Michael D. Winniford, MD, FACC†

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Cites background from "Regional anesthesia in the patient ..."

...In the United States, however, concerns about the potential for neuraxial bleeding (particularly in the setting of heparinization, platelet inhibitors, and CPBinduced thrombocytopenia), local anesthetic toxicity, and logistical issues related to the timing of epidural catheter insertion and management have resulted in limited use of these techniques (22)....
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References

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Goodman and Gilman's the Pharmacological Basis of Therapeutics

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William H. Stigelman, Pharm D.

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Goodman & Gilman's The Pharmacological Basis of Therapeutics

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Laurence L. Brunton

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TL;DR: Goodman and Gilman's the pharmacological basis of therapeutics , Goodman and Gilmann's the pharmaceutica basis for drug discovery, and more.

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Abstract: In 1940, the world of pharmacology was revolutionized by the appearance of the first edition of this now-classic text. Edited by Lou Goodman and Al Gilman, it was a joy to read and a beacon in the darkness for teachers, students, and practitioners. (I can recall physicians saying they kept it on their bedside table for their nightly reading and pleasure.) The new edition remains a competently written and authoritative book, although it is now put together by 58 people instead of two, with the inevitable problems posed by such a division of labor. (One may envy the editors and the publishers the income from this best seller, but not the task of nagging recalcitrant authors with no respect for deadlines.) One may question, however, as in recent editions, the wisdom of combining a textbook for students and a reference for physicians. Those of us who teach second-year medical students

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Prevention of venous thromboembolism

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Willitim Geerts¹, Joel C. Ray¹, Clifford W. Colwell¹, David Bergqvist¹, Graham F. Pineo¹, M. R. Lassen¹, John A. Heit¹ - Show less +3 more•Institutions (1)

University of Toronto¹

01 Oct 1992-Chest

TL;DR: The risk factors for VTE among hospitalized patients are outlined, the efficacy and safety of alternative prophylaxis regimens are reviewed, and recommendations regarding the most suitable prophymic regimens based on the estimated risk are provided.

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Prevention of Venous Thromboembolism* American College of Chest Physicians Evidence- Based Clinical Practice Guidelines (8th Edition)

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William H. Geerts¹, David Bergqvist, Graham F. Pineo², John A. Heit³, Charles M. Samama, Michael R. Lassen, Clifford W. Colwell⁴ - Show less +3 more•Institutions (4)

Sunnybrook Health Sciences Centre¹, University of Calgary², Mayo Clinic³, Scripps Health⁴

01 Jun 2008-Chest

TL;DR: This article discusses the prevention of venous thromboembolism (VTE) and is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

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3,944 citations

"Regional anesthesia in the patient ..." refers background or methods in this paper

...Rather, such patients can continue to be treated with twicedaily subcutaneous UFH and the use of compression devices.(7) Furthermore, it is not necessary to routinely check the aPTT or platelet count, unless the clinician is concerned about changes in these values after Bprolonged administration[ or in patients with many comorbidities that might influence the pharmacologic expression of subcutaneous UFH....
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...This may be in part due to low adherence to the prescribed balance of thromboembolic complication and bleeding, a difference in patient population (controlled study patients with few comorbidities versus actual clinical practice) and the use of a surrogate end point.(7,21) In addition, because previous studies have not included patients at risk for increased bleeding, the balance between hemostasis and thromboembolism in these patients is even less clear....
[...]
...Guidelines for antithrombotic therapy including appropriate pharmacologic agent, degree of anticoagulation desired, and duration of therapy continue to evolve.(6,7) Recommendations from the Eighth ACCP Guidelines on Antithrombotic and Thrombolytic Therapy in 2008 are based extensively on clinical trials that assessed the efficacy of therapy using contrast venography or duplex sonography to diagnose asymptomatic thrombi....
[...]
...§Adapted from the American College of Chest Physicians.(7) Horlocker et al Regional Anesthesia and Pain Medicine & Volume 35, Number 1, January-February 2010...
[...]
...Subcutaneous Heparin With Thrice-Daily Dosing It has become conventional treatment for patients to receive subcutaneous UFH 3 times per day rather than 2 times per day based on the 2008 ACCP conference guidelines.(7) There are scarce data that aid the practitioner in determining the risk and benefit ratio for patients who would otherwise benefit from single-shot regional anesthesia/analgesia or request epidural analgesia or peripheral nerve block analgesia maintained postoperatively while receiving such therapy....
[...]

Journal Article•DOI•

Prevention of VTE in Nonsurgical Patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

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Yngve Falck-Ytter¹, Charles W. Francis², Norman A. Johanson³, Catherine Curley¹, Ola E. Dahl, Sam Schulman⁴, Thomas L. Ortel⁵, Stephen G. Pauker⁶, Clifford W. Colwell⁷ - Show less +5 more•Institutions (7)

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