Journal ArticleDOI
Regional wall mechanics in the ischemic left ventricle: numerical modeling and dog experiments
Peter H. M. Bovendeerd,Theo Arts,Tammo Delhaas,Jacques M. Huyghe,D.H. van Campen,R. S. Reneman +5 more
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TLDR
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate.Abstract:
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate. Ischemia was modeled by disabling the generation of active stress in a region comprising approximately 12% of total wall volume. In the model simulations, the approximately 12% reduction in the amount of normally contracting tissue resulted in an approximately 25% reduction in stroke work compared with the normal situation. The more-than-proportional loss of stroke work may partly be attributed to storage of elastic energy in the bulging ischemic region. Furthermore the mechanical performance in the nonischemic border zone deteriorated because of reduced systolic fiber stress (if fibers were in series with those in the ischemic region) or reduced fiber shortening (if fibers were parallel). The deformation pattern of the ventricle was asymmetric with respect to the ischemic region because of the anisotropy of the myocardial tissue. Epicardial fiber shortening in and around the ischemic region, as predicted from the model simulations, was in qualitative agreement with shortening, as measured in four dogs in which ischemia was induced by occlusion of the distal part of the left anterior interventricular coronary artery.read more
Citations
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Incorporation of a Left Ventricle Finite Element Model Defining Infarction Into the XCAT
TL;DR: In this paper, a finite element (FE) model of the left ventricle (LV) was used to simulate motion abnormalities caused by myocardial infarction (MI), a far more complex situa- tion in terms of altered mechanics compared with the modeling of acute ischemia.
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Integrative models for understanding the structural basis of regional mechanical dysfunction in ischemic myocardium.
Reza Mazhari,Andrew D. McCulloch +1 more
TL;DR: How anatomically detailed, three-dimensional computational models can be used in conjunction with experimental or clinical studies to elucidate the structural basis of regional dysfunction in acutely isChemic and ischemic-reperfused (“stunned”) myocardium in vivo is described.
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Modeling Cardiac Electromechanics and Mechanoelectrical Coupling in Dyssynchronous and Failing Hearts: Insight from Adaptive Computer Models
TL;DR: Basic modules that can be identified in multi-scale models of cardiac electromechanics are described and well-chosen applications show promising results on some ultimate goals: understanding mechanisms of dyssynchronous heart failure and tuning pacing strategy to a particular patient, even before starting the therapy.
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Regional myocardial mechanics: integrative computational models of flow-function relations.
Andrew D. McCulloch,Reza Mazhari +1 more
TL;DR: 3- dimensional computational models are able to reproduce many complex features of the 3- dimensional patterns of regional myocardial deformation observed experimentally and it is suggested possible roles for such integrative models in clinical diagnosis.
Journal ArticleDOI
Left ventricular wall stress compendium.
TL;DR: This paper can enable readers to obtain a comprehensive perspective of left ventricle wall stress models, of how to employ them to determine wall stresses, and be cognizant of the assumptions involved in the use of specific models.